Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism
academic.oup.com/jcem/artic...
The rationale behind thyroid hormone replacement therapy is to administer thyroid hormone in a way that restores thyroid hormone signaling in all tissues.
There it is in black and white!
When will they stop focussing on TSH which is causing problems for many people
In conclusion, some patients on LT4 therapy remain symptomatic despite normal serum TSH levels. In the present investigation, the number of these patients was not sufficiently large to affect the outcomes of the whole group. However, in the subset analysis, these patients were identified as having the worst performance on QoL questionnaires and cognitive tests. These patients were also the ones that preferred and benefitted from switching to therapy containing T3, either DTE or LT4 + LT3 combination, suggesting that thyroid hormone signaling in a minority of the patients on LT4 remain subnormal and can be improved (perhaps restored) with therapy containing T3.
[Published in: The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021 ]
