B12 - advice on injections please

[TheMudRunner]

Hi, can anyone tell me if there is a reason you should have Hydroxycobalbumin rather than Methylcobalbumin form of B12 injected..? Hydroxycobalbumin is the precursor of the other with Methylcovalbumin being the active form (from what I can tell) and both seem to be available in the UK for injection.

Thank you 😀

[TheMudRunner]

I can’t edit the post, but I misspelt the drug names. These should be:

Hydroxycobalamin and Methylcobalamin

Apologies 😀

[bookish in reply to TheMudRunner]

Hi, the NHS only provides hydroxo for injection in the vast majority of cases. Rarely also provide cyanocobalamin for those who react to hydroxo, but I believe they may be stopping. Cyano is the tablet form for those who are prescribed oral. You can buy all 4 forms to self inject, I believe and some inject more than one form. I used hydroxo, methyl and adenosyl tablets and sublinguals but needed injections and have recently started prescribed hydroxo. Some need more methyl groups, which come from methylfolate rather than methylcobalamin, but others don't do well with additional methyl at all. Methylcobalamin is less stable and more expensive, but some find hydroxo doesn't work for them, just like cyano may not. We are all different. You could try the pernicious anaemia forum with your question, although there are others here who have both thyroid and PA or B12 D issues, so hopefully you'll get some more replies. Cheers

[RedApple Administrator]

TheMudRunner, you might get more input for your question if you ask on the PA forum here healthunlocked.com/pasoc/about