Positive TPO: Hello everyoneIve had a positive... - Thyroid UK

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Positive TPO

Ticman profile image
9 Replies

Hello everyoneIve had a positive TPO result and told not to worry will retest in 3 months as its not particurly high. Ive been reading a lot of posts on here recently and im of the view point now it is quite high. Whats peoples views?

TPO 105 ( RANGE 35)

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Ticman
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Ticman profile image
Ticman

TSH 5.1 (5.5)

FREE T4 11.8 l10-20)

T3 5.4 (3.5-6.5)

TPO 105 (35)

Bloods taken 3.30pm also which i believe cause lower results?

Will make sure next time i get bloods done early morning before food.

Thanks

greygoose profile image
greygoose in reply toTicman

Yes, it is high, and definitely positive. You have Hashi's - aka Autoimmune Thyroiditis. And, even it the antibodies drop lower in the next test, you will still have Hashi's. Antibodies fluctuate all the time.

Your TSH is also high, but not high enough to get you a diagnosis of hypo, I'm afraid. It would have to be over the the magic cut-off point: the top of the range! One point below that and there can't possibly be anything wrong with you, even if you're on your knees! 🙄

Ticman profile image
Ticman in reply togreygoose

Thankfully im not on my knees yet but i get the feeling its only a matter of time!

greygoose profile image
greygoose in reply toTicman

Yes, I'm afraid you're right, there.

SlowDragon profile image
SlowDragonAdministrator in reply toTicman

high thyroid antibodies and high TSH and low Ft4 shows you have autoimmune thyroid disease

Retest 6 weeks after first test

Definitely test early morning, ideally just before 9am, only drink water between waking and test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

You need two tests with TSH over 5 before starting on levothyroxine

Starting levothyroxine - flow chart

gps.northcentrallondonccg.n...

meanwhile get Vitamin D, folate, B12 and ferritin levels tested …..quite likely low levels already

Plus coeliac test

nice.org.uk/guidance/ng20/c...

1.1 Recognition of coeliac disease

1.1.1 Offer serological testing for coeliac disease to:

people with any of the following:

persistent unexplained abdominal or gastrointestinal symptoms

faltering growth

prolonged fatigue

unexpected weight loss

severe or persistent mouth ulcers

unexplained iron, vitamin B12 or folate deficiency

type 1 diabetes, at diagnosis

autoimmune thyroid disease, at diagnosis

irritable bowel syndrome (in adults)

first‑degree relatives of people with coeliac disease.

Ticman profile image
Ticman in reply toSlowDragon

Thanks for the links very informative.My last coeliac blood test result was <0.5 (0-14.9)

Just had a look online and i think that is good?

SlowDragon profile image
SlowDragonAdministrator in reply toTicman

Hashimoto's affects the gut and leads to low stomach acid and then low vitamin levels

Low vitamin levels affect Thyroid hormone working

Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances.

Most common by far is gluten.

Dairy is second most common.

A trial of strictly gluten free diet is always worth doing

Only 5% of Hashimoto’s patients test positive for coeliac but a further 81% of Hashimoto’s patients who try gluten free diet find noticeable or significant improvement or find it’s essential

A strictly gluten free diet helps or is essential due to gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and may slowly lower TPO antibodies

as coeliac test is negative you can trial strictly gluten free diet 

Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse

chriskresser.com/the-gluten...

amymyersmd.com/2018/04/3-re...

thyroidpharmacist.com/artic...

drknews.com/changing-your-d...

Non Coeliac Gluten sensitivity (NCGS) and autoimmune disease

pubmed.ncbi.nlm.nih.gov/296...

The predominance of Hashimoto thyroiditis represents an interesting finding, since it has been indirectly confirmed by an Italian study, showing that autoimmune thyroid disease is a risk factor for the evolution towards NCGS in a group of patients with minimal duodenal inflammation. On these bases, an autoimmune stigma in NCGS is strongly supported

nuclmed.gr/wp/wp-content/up...

In summary, whereas it is not yet clear whether a gluten free diet can prevent autoimmune diseases, it is worth mentioning that HT patients with or without CD benefit from a diet low in gluten as far as the progression and the potential disease complications are concerned

restartmed.com/hashimotos-g...

Despite the fact that 5-10% of patients have Celiac disease, in my experience and in the experience of many other physicians, at least 80% + of patients with Hashimoto's who go gluten-free notice a reduction in their symptoms almost immediately.

Similarly few months later consider trying dairy free too. Approx 50-60% find dairy free beneficial

With loads of vegan dairy alternatives these days it’s not as difficult as in the past

Post discussing gluten

healthunlocked.com/thyroidu...

Ticman profile image
Ticman in reply toSlowDragon

Thank you very much its appreciated.

Ticman profile image
Ticman

Thank you for replies

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