Thyroid Replacement Therapy and Heart Failure
Anthony Martin Gerdes and Giorgio Iervasi
Originally published27 Jul 2010doi.org/10.1161/CIRCULATION.... 2010;122:385–393
Heart failure (HF) is a major public health and economic problem in Western countries and is one of the most common causes of hospitalization and death. Coronary artery disease is the underlying cause in more than two thirds of chronic HF patients. By 2020, the World Health Organization projects that ischemic heart disease alone will be the most important global cause of morbidity and mortality. The estimated increases in HF-related morbidity and mortality suggest that our understanding of the pathophysiological mechanisms of this syndrome is inadequate.