Dose Increase?: Hello, I have been battling to... - Thyroid UK

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Dose Increase?

jenny876 profile image
9 Replies

Hello, I have been battling to get a levothyroxine prescription for weeks and after getting Hashimotos diagnosis. My latest results are from 24th November:

T4 12.7 (12-22)

TSH 4.18 (0.27 - 4.20)

I have been taking half of a 25mcg levothyroxine since 29th October until 27th November (4 weeks) as I had a packet of them left over from June when I was last taking Levo and knew I would run out before getting another prescription so thought it was better to take small dose than none and try to make them last.

I got a new prescription so started on 25mcgs on 28th November until now (2 weeks). I have terrible symptoms and feel I have been undermedicated for so long and was wondering if it would be possible to up my dose to 50mcgs?

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TiggerMe profile image
TiggerMe

Yes, definitely! Unless you are petite you are going to need to increase to a full replacement dose, as a rough idea how much do you weigh?

Taking a little will just shut down any natural production your body is capable of

jenny876 profile image
jenny876 in reply to TiggerMe

Im 9 stone.

TiggerMe profile image
TiggerMe in reply to jenny876

A rough guide is 1.6 per kilo so you'll likely find your optimal dose somewhere between 75-100 it rather depends how well you absorb and convert... increase (no more than 25mcg) and test every 6-8 weeks and as you get closer to your optimal dose make smaller increases as you don't want to over shoot 🤗

jenny876 profile image
jenny876 in reply to TiggerMe

Thank you so much - ive been feeling so depressed and get no help from GP/endo whihc makes me feel so alone but this forum and very helpful people like you are such a comfort and a wealth of knowledge - thank you! :-)

TiggerMe profile image
TiggerMe in reply to jenny876

It is a lonely place dealing with some medics... we are all here for you, having all walked this path 🙃

SlowDragon profile image
SlowDragonAdministrator

your Ft4 is far, far too low because you are on inadequate dose Levo

Aiming for Ft4 ( levothyroxine) at least 70% through range

Recommended that all thyroid blood tests early morning, ideally just before 9am, only drink water between waking and test and last dose levothyroxine 24 hours before test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

If sensitive to changes in dose …..Increase to 25mcg and 50mcg on alternate days initially …..then after 4-6 weeks increase to 50mcg daily

Retest in 6-8 weeks after that

As TiggerMe says….you’re likely to eventually be on something between 75mcg and 100mcg daily

Which brand of levothyroxine are you currently taking

jenny876 profile image
jenny876 in reply to SlowDragon

Im taking Teva which I initially thought didnt agree with me but am finding it okay. Alternate dosing of 25mcgs one day and 50mcgs the next is a great idea because I dont see my endo until 10th January so that will mean I wont run out of tablets before I see them.

I havent had my vitamin levels checked again but will do this in January - have been taking Vit b12, iron and Vit D. Strictly Gluten free and 2 coeliac tests showed negative. thank you

SlowDragon profile image
SlowDragonAdministrator in reply to jenny876

Rather than just B12, add in a separate vitamin B complex as well

With serum B12 result below 500, (Or active B12 below 70) recommended to be taking a separate B12 supplement and a week later add a separate vitamin B Complex 

Then once your serum B12 is over 500 (or Active B12 level has reached 70), you may be able to reduce then stop the B12 and just carry on with the B Complex.

If Vegetarian or vegan likely to need ongoing separate B12 few times a week

B12 drops

natureprovides.com/products...

Or

B12 sublingual lozenges

uk.iherb.com/pr/jarrow-form...

cytoplan.co.uk/shop-by-prod...

B12 range in U.K. is too wide

Interesting that in this research B12 below 400 is considered inadequate

healthunlocked.com/thyroidu...

Low folate

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid)

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

healthline.com/nutrition/fo...

Many Hashimoto’s patients have MTHFR gene variation and can have trouble processing folic acid.

thyroidpharmacist.com/artic...

B vitamins best taken after breakfast

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule)

Thorne currently difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

Other options

healthunlocked.com/thyroidu....

Igennus B complex popular option too. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg) and continue separate B12

Post discussing how biotin can affect test results

healthunlocked.com/thyroidu...

helvella.blogspot.com/p/hel...

SlowDragon profile image
SlowDragonAdministrator

have you had coeliac blood test

Are you now on strictly gluten free diet?

Ferritin X 23.50 ug/L (Range: 30 - 150)

Folate - Serum 15.1 nmol/L (Range: 8.83 - 60.8)

Vitamin B12 - Active 52.2 pmol/L (Range: 37.5 - 188)

Vitamin D X 49.9 nmol/L

Vitamin levels 4 months ago

Exactly what vitamin supplements are you taking now

Have you retested since ?

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