Thyroid Hormone Transport into Cellular Tissue - Thyroid UK
Thyroid Hormone Transport into Cellular Tissue
Oh my goodness DippyDame what a great article!
This bit is sweet.
Reduced T4 and T3 transport into the cells in peripheral tissues is seen with a wide range of common conditions, including insulin resistance, diabetes, depression, bipolar disorder, hyperlipidemia, chronic fatigue syndrome, fibromyalgia, neurodegenerative diseases, migraines, stress, anxiety, chronic dieting and aging, while the intracellular T3 level in the pituitary often remains unaffected.
Bookmarking. Thanks for sharing.
Reduced T4 and T3 transport into the cells in peripheral tissues is seen with a wide range of common conditions, including insulin resistance, diabetes, depression, bipolar disorder, hyperlipidemia, chronic fatigue syndrome, fibromyalgia, neurodegenerative diseases, migraines, stress, anxiety, chronic dieting and aging, while the intracellular T3 level in the pituitary often remains unaffected.
What exactly is he saying here? That reduced T4/T3 transport into cells causes these conditions? Or that these conditions cause reduced T4/T3 transport etc. It's not clear. Although he says it three times!
If it's the former, then we already know all that - typical symptoms of hypothyroidism. If it's the latter, I have my doubts.
I think we can sum this article up by saying:
- TSH is a bad indicator of thyroid status (for many reasons)
- Blood tests only tell you what is in the blood, not what is getting into the cells.
We already know these things. Is there anything new that I have missed?
To be clear I think it the former, though I agree it could be interpreted the other way. But for clarification on your latter point, who exactly is 'we' greygoose? You have a lot of knowledge and are very aware of these things, I might know these things, though still having a somewhat vague understanding of the underlying mechanisms involved, but many people who frequent this forum may still not know. And regardless, I like papers that acknowledge the possible causes of my suffering, because I don't get it in the healthcare system, which therefore keeps me ill, and not just ill, but ill to the point of functional disability. And as you know too well, I have relied on information from people such as yourself on the forum to get anywhere within 10 feet of normal. So, personally, I cannot hear the same points repeated enough from any source. There aren't enough papers in all the world linking the aforementioned conditions to low T3 uptake in the cells (in either direction) as far as I'm concerned.
I am very happy this article was posted, and shall continue reading it whilst eating my supper later.
I just meant 'we' the patients in general. Not all patients, of course. We all have to start learning somewhere. And, of course, not any doctors as far as I can see! But it was just the tone of the article that irritated me. He writes as if he's discovered something new that nobody else has ever thought of! I was expecting some new revelation, that's all.
Beware that this chap has written articles with many errors. It's a massive job to verify this paper as nothing is referenced, just a list of hundreds of studies he may or may not have studied. I would ignore it as it's very difficult to unlearn false information.
My philosophy is to ignore nothing but to read with an open mind.
Better to have a critical mind. Ask why is the article so vague? Why isn't each assertion backed up with a specific reference? How can you check each claim if there is no attempt to reference it? A previous article on deiodinase by him had approximately 50% errors, you couldn't even invert his assertions to get closer to the facts.
It would be interesting to read what the Reviewers wrote before publication in the Journal.
KH appears to be on the journal's Editorial Review Committee!
Take your point!
I don’t. It’s up to everyone to read things with a critical mind - and I strongly resent any assertion that I don’t do that.
There are many errors on a thyroid website not far from here. I always suggest that people who use this site should ‘fact check’ all the information that’s on that.
Everywhere2, 'There are many errors on a thyroid website not far from here. I always suggest that people who use this site should ‘fact check’ all the information that’s on that.'
I would also strongly suggest that we can all play a part in reporting such errors to the site owner wherever and whenever possible. If we don't, then these 'errors' will likely continue to go uncorrected.
My point was, that before publication in a Journal, as this paper was, a submission is reviewed (for corrections)....that review clearly isn't published. So, it doesn't tell the reader anything as you seem to suggest, or prevent them from forming their own critical review. My comment was basically an aside.
Also, there was no "assertion" that you do not read published articles etc with a critical mind. I'm sorry if you felt that was implied
I'm suggesting we ignore it because it is typical of articles that make vague assertions and use hundreds of non-specific references to give an impression of evidence. Feel free to read it and take a critical view, but do you have the time to read it carefully and study the 205 referenced papers?
So, to a general audience I would suggest ignore it. Of course this is just my opinion.
I'm a bit run down at the moment so don't have time to read this article and follow it up. I will raise a couple of examples that leap out from having skimmed the paper, I know this is bad practice. I am also citing studies I have not referenced which I hope people will excuse just this once, I've not got the energy. I cite studies that were published prior to Holtorf's paper.
He asserts "The pituitary has different transporters than every other tissue in the body.", a very important claim but he fails to reference any evidence. THIS SIMPLY ISN'T TRUE. It is described here etj.bioscientifica.com/view... which cites in reference 22 as the original study. He again asserts "the pituitary has completely different transporters" a little later on.
Many of the statements in this article are correct, many are wrong, we won't know what is right and what is wrong unless we already know, or have substantial time to verify each sentence. Read it at your peril.
Hello Jim. I’m sorry you’re not feeling great. Thanks for taking the time to write this post.
I take your point.
Best wishes
Very interesting. Thank you DD
This is a great find DippyDame. Thank you.
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