Dio1 homozygous?

[perardua]

Hi, can someone just confirm this for me, I'm quite sure I'm reading it right from reading P Robinson's blog and others posts on here but wanted to double check. I've just searched my 23andme data.

AA in this gene means homozygous and is the risk gene, is that correct? As opposed to the C allele which boosts Dio1 expression.

Thanks.

[Jaydee1507 Administrator]

I think you are correct. I've just been reading on self decode.

selfdecode.com/app/article/...

SNP Summary

DIO1 rs2235544 [R]

‘A’ = normal DIO1 activity and T3 levels

‘C’ = more active DIO1, correlates with higher T3 levels

[perardua in reply to Jaydee1507]

Hi, I read this too and this is what confused me, because I think Selfdecode is incorrect as per:

paulrobinsonthyroid.com/dio...

He seems to say T or A is the risk gene, ie the allele connected with impaired conversion, whereas C is the allele where Dio1 is boosted. So AA should be the 'poor' gene inherited from both parents. It may not be that Selfdecode is incorrect, but I think they use different letters to mean different things depending on the provider.

See also:

frontiersin.org/articles/10...

In their study the 'AA' type do better on T4/T3 therapy, whereas the 'CC' are ok on T4 only.

[Jaydee1507 Administrator in reply to perardua]

Perhaps they have worded it badly but I read that C is boosted which does agree with Paul Robinson but not in so many words.

I do know I have 1 faulty DIO2 and also 1 faulty DIO1 and I do better on a Levo/T3 combo.

[Auders]

interesting post, I’ve just received my 23andme kit, bought it on Amazon prime for £99. I’ll have a spitting day tomorrow 🤭

[TiggerMe in reply to Auders]

Which one did you go for? I'm not seeing a £99 one? No doubt the price has gone back up

[Auders in reply to TiggerMe]

hello, it was the premium membership and genetic insights. I’ve just checked and it’s gone back to £169!