DI 02 effects beyond thyroid

[Ruthi]

I am one of the many who don’t get on with Levothyroxine. When I got up to the maximum dose without feeling better my consultant tried liothyronine which made me feel instantly livelier, but I had nasty side effects so ended up on NDT. I have to be at or slightly above top of the range to feel good and have taken Thyroid S for about 20 years with GP testing.

Nearly 10 years before my thyroid gave up I was tested and found positive for osteoporosis because of a family history. And now my son has also been diagnosed aged 46. I read somewhere that the DI02 gene is also linked to early osteoporosis. I would like to find out more, and also whether it is linked to other conditions. Can someone point me in the direction of any research? I’m concerned that we investigate early for my grandchildren - my son already has a 10% risk of fracture!

I do realise these things are multi factorial, but want to do as much as possible!

[Robinsca]

Hi I have been on T3 for over 30. Years since I had thryroid and parathyroids removed for cancer.

T3 suits me as my body does not absorb Levothyronine. I take 40 mcg on waking and 40 mcg midday, but my GP has cut that down to one at Midday - already feeling hypo. However with the new restrictions of only allowing 10 mcg per patient per day - I find myself in a serious dilemma - to withhold a life essential drug ( like thousands of others in this position) is going to cause serious harm and I do not know the way forward. I am too old to move to Greece where it is available off the shelf!! Wishing you well

Chris Fraser

[TiggerMe in reply to Robinsca]

I don't understand how a GP has the right to reduce your T3 dose it would have to be done by an Endo as GP's have no powers to do this! The fact they would even cut your dose so drastically shows a total lack of understanding... I would insist it is reinstated until an Endo referral has been sorted 😡

[Bearo]

I found this from a previous post:

Another study showing effect of DIO2 polymorphism when on T4•

This study shows that anxiety and depression scores are higher in people homozygous for DIO2 polymorphism when on T4, (but not if they are not given T4) and quality of life is poorer.

endocrine abstracts.org/ea/...

Also:academic.oup.com/jcem/artic..

.Common Variation in the DIO2 Gene Predicts Baseline Psychological Well-Being and Response to Combination Thyroxine Plus Triiodothyronine Therapy in Hypothyroid Patients

Vijay Panicker, Ponnusamy Saravanan, Bijay Vaidya, Jonathan Evans, Andrew T. Hattersley, Timothy M. Frayling, Colin M. Dayan