We have just had this paper accepted. Because of its rarity of its encouraging tone and to boost my ego more, I've included the whole of the acceptance comments. It adds to our last paper describing the mechanism of thyroid function and control.
It is a pleasure to accept your manuscript entitled
"The Role of Supporting and Disruptive Mechanisms of FT3 Homeostasis in Regulating the Hypothalamic-Pituitary-Thyroid Axis"
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Thank you again for your fine contribution.
On behalf of the Editors of Therapeutic Advances in Endocrinology and Metabolism, we look forward to your continued contributions to the Journal.
Sincerely, Dr Joanna Klubo-Gwiezdzinska Associate Editor, Prof. Dr. med. Christoph Schindler, M.D.Editor-in-Chief
Reviewer(s)' Comments to Author:This is cutting edge material adding to the discussion of thyroid physiology. The T3/T4 discussion remains unsettled but this work should encourage more consideration of the question. Previous comments and corrections have been attended satisfactorily.
Editor(s)' Comments to Author: Congratulations, very well done. Thanks for this fine contribution.
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Now this is out of the way, we are on an eBook to summarise all our findings and thereby give a proper role for diagnosis and treatment. Also, because of the different performance of different FT4/3 assays, we criticise amalgamating studies e.g meta-analyses that have that problem. If you look, the whole of present thyroidology is very threadbare. And rests on quite crude analysis. We want to bring in a bit more disinterested ( ie neutral) argument into this. Hopefully, this should cut off the negative ripostes by the accepting community.
To boost my ego cracked me up and made my evening. Honestly seeing straight up honesty is refreshing. Congrats to you and thanks for advancing our cause
The more people apply their minds to HPT stuff the more it will become mainstream medical knowledge .And the less people,I'm afraid mostly female, will suffer the " death of a thousand cuts " that is the lot of those with HTP axis illness. Bravo
And is the extract below ** about with downregulation of tsh response ( which I need to show my GP to convince him that so called "in range" tsh blood numbers doesn't necessarily mean that he can ignore and refuse t4 meds to me when it is accompanied by a t4 reading which is 40% below minimum of the "in range " figure
Extract **"...This supports the concept of a dampened response and multistep regulation, making the interactions between TSH, FT4, and FT3 situational and mathematically more complex..."
This article was published in the rather earlier days of our quest, but its findings are no less relevant. What has happened in the meantime is that we've developed as it were the skeleton to put the flesh on correctly in the right places. Strengthening the argument with both mathematical modelling and the obedience of real patient numbers to agree,
Worry not! I'll parenthesise the paper into its main conclusions (avoiding the necessary mathematics which is the basis of the argument): that is, is our model in harmony with observed data. That's the key act to do - otherwise everything is propaganda, and there's far too much already.
Yes , this makes total sense to me a litigation lawyer in former life ....you have to PROVE a case with evidence, you have to corroborate evidence with other evidence ,one bit is not enough, wishful thinking doesn't cut the mustard , we can't believe what we want to believe, this is because we might be wrong , the only thing that is credible is when we follow the evidence wherever it takes us even if we prove wrong what would make our lives easier if it were right . I don't "get" all the technical stuff but I sometimes "get" your conclusions ...And I believe them because of the process you follow . Unlike my GP who takes the path of least resistance. ..the flat earth process ,which is why he says I'm "borderline " hypothyroidal because my tsh is in range but low, he refuses meds even though when my T 4 reading is 40%below minum range and I have numerous symptoms . Happy Christmas and may the force be with you
I'm scared to do so for fear of being blacklisted in small.town.Also When in 2018 I asked for second opinion ,( which I paid for privately for speed) the consultant said the same as GP with T4 levels.of 8 ( range 12- 22)
My friend a GP in another part of the country said it was something called "professional etiquet" . In the litigation world where I come from ,fellow professionals can't wait to challenge each other ( that's the name of the game) But in.medical world it seems that all " you scratch my back and I'll scratch yours"
Thank you. Your work is valuable and thank goodness you’re broadcasting it. Well done and look forward to reading it - please post a link when you can.
Really pleased for you - hopefully makes all the blood sweat and tears worth it! Thanks again for all the hard work you have put into improving things for thyroid patients.
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