Switching from Hydrocortisone to Prednisolone - Thyroid UK

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Switching from Hydrocortisone to Prednisolone

NiceDay49 profile image
4 Replies

Hi, I've been taking Hydrocortisone for secondary adrenal insufficiency since 2017 after partial removal of a craniopharyngioma. I've been experiencing more fatigue and poor sleep issues recently and it was suggested that I could trial Prednisolone to see it it helped. I wondered if anyone has switched to Prednisolone, and why and if you feel any different, better or worse and if it helped. I know the default is Hydrocortisone but I don't know why some people start of on Prednisolone and what the criteria is for prescribing it. Any information welcome.

Thank you

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NiceDay49
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bagpuss61 profile image
bagpuss61

Just out of curiosity, have you been tested for low Aldosterone? I too take HC and didn't feel better after 9 months, it turned out I had low aldosterone and now add fludrocortisone, I feel much better with that.

stopthethyroidmadness.com/a...

NiceDay49 profile image
NiceDay49 in reply tobagpuss61

Well no, not to my knowledge. I confess I'd not heard of it before so I just googled it.

I'm taking desmopressin for diabetes insipidus. I don't have Addisons. I had a recent blood test for iron, vitamin B12, kidney function etc and all fine. I'll mention fludrocortisone to my endo consultant next time I see him

Are you taking Prednisolone?

bagpuss61 profile image
bagpuss61 in reply toNiceDay49

No I take hydrocortisone 26 mcg a day and I don't have Addisons, I have 24 hr low cortisol. Read the link I sent you, and see if you can relate to it and the symptoms. If you can, then you can request a low Aldosterone test. Then its up to consultant whether to put you on fludrocortisone.

NiceDay49 profile image
NiceDay49 in reply tobagpuss61

Thanks, I checked the link and will mention it to my Endo consultant next time.

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