Switching from Hydrocortisone to Prednisolone

[NiceDay49]

Hi, I've been taking Hydrocortisone for secondary adrenal insufficiency since 2017 after partial removal of a craniopharyngioma. I've been experiencing more fatigue and poor sleep issues recently and it was suggested that I could trial Prednisolone to see it it helped. I wondered if anyone has switched to Prednisolone, and why and if you feel any different, better or worse and if it helped. I know the default is Hydrocortisone but I don't know why some people start of on Prednisolone and what the criteria is for prescribing it. Any information welcome.

Thank you

[bagpuss61]

Just out of curiosity, have you been tested for low Aldosterone? I too take HC and didn't feel better after 9 months, it turned out I had low aldosterone and now add fludrocortisone, I feel much better with that.

stopthethyroidmadness.com/a...

[NiceDay49 in reply to bagpuss61]

Well no, not to my knowledge. I confess I'd not heard of it before so I just googled it.

I'm taking desmopressin for diabetes insipidus. I don't have Addisons. I had a recent blood test for iron, vitamin B12, kidney function etc and all fine. I'll mention fludrocortisone to my endo consultant next time I see him

Are you taking Prednisolone?

[bagpuss61 in reply to NiceDay49]

No I take hydrocortisone 26 mcg a day and I don't have Addisons, I have 24 hr low cortisol. Read the link I sent you, and see if you can relate to it and the symptoms. If you can, then you can request a low Aldosterone test. Then its up to consultant whether to put you on fludrocortisone.

[NiceDay49 in reply to bagpuss61]

Thanks, I checked the link and will mention it to my Endo consultant next time.