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High intensity focused ultrasound in the therapy of benign thyroid nodules-first German bicentric study with long-term follow-up

helvella profile image
helvellaAdministrator
5 Replies

This trial could be interesting. After all, ultrasound avoids the issues of radiation present in some other treatments. And also avoids surgery with all its issues.

Endocrine. 2022 Apr 27.

doi: 10.1007/s12020-022-03058-z. Online ahead of print.

High intensity focused ultrasound in the therapy of benign thyroid nodules-first German bicentric study with long-term follow-up

Christian Vorländer 1 , Anne Fischer 2 , Hüdayi Korkusuz 3

Affiliations

• PMID: 35476180

• DOI: 10.1007/s12020-022-03058-z

Abstract

Purpose: The study evaluated high-intensity-focused ultrasound (HIFU) for benign thyroid nodules in terms of efficiency, complication rate, influence of preablative nodule size, parameters influencing the therapeutic success and hormonal-thyroid-function.

Methods: Seventy-two patients with 75 nodules were treated with HIFU at 2 centers from 2014-2019. Median nodule volume was 4.4 ml (range 0.33-53). The therapeutic ultrasound probe (EchoPulse THC900888-H) generated 80-90 °C in the target tissue with 87.6-320.3 J per sonication. Nodal volume was measured at baseline and over 12 months after therapy in a retrospective bicentric-study with long-term follow-up. Hormonal-thyroid function (TSH, T3, T4) was measured before and after ablation. Complications were assessed.

Results: Significant volume reduction (p < 0.05 Wilcoxon-signed-rank test) of thyroid nodules was 38.98% at 3 months, 37.32% at 6 months, 61.54% at 9 months and 60.66% at 12 months. Volume reduction of nodules <3 ml did not differ significantly from nodules >3 ml (p > 0.05 Mann-Whitney test). At 3 months solid nodules had a significant volume reduction of 52.08%, complex nodules of 32.57%, nodules treated under regional anesthesia of 33.07% and under general anesthesia of 49.47%. Hormonal-thyroid function was not influenced significantly by HIFU therapy (p > 0.05 Wilcoxon-signed-rank test). Complication rate was 3.8%. No long-term complications occurred.

Conclusion: Significant volume reduction of thyroid nodules up to 12 months after HIFU was shown. All complications were reversible. Therapy was more efficient in solid than complex nodules and in nodules treated under general anesthesia than with regional anesthesia. Hormonal-thyroid-function was not affected.

Trial registraftion number: 2020-1728-evBO. Date of registration: 16.06.2020. Agency: Ethik-Kommission bei der Landesäztekammer Hessen.

Keywords: Benign thyroid nodules; High intensity focused ultrasound; Thermoablative procedure; Volume reduction.

Usual paywall issue prevents access to full paper.

pubmed.ncbi.nlm.nih.gov/354...

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nightingale-56 profile image
nightingale-56

Sounds like a much better treatment than RAI or Thyroidectomy if it works. Thanks for posting helvella .

Hedgeree profile image
Hedgeree

Helvella,

Is this the same type of ablation treatment that two NHS hospitals are starting to offer now?

If I remember correctly it was referred to in another post a few weeks back?

helvella profile image
helvellaAdministrator in reply toHedgeree

Trying to remember what sort was mention - I know radio-frequency and ethanol (alcohol) techniques have been/are being used.

helvella profile image
helvellaAdministrator in reply toHedgeree

This is a link to a search which found a few occurrences of "ablation".

healthunlocked.com/thyroidu...

Hedgeree profile image
Hedgeree in reply tohelvella

Thank you.

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