100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats

[helvella]

An interesting paper on vitamin D.

I recommend reading the conclusion - not just the abstract.

100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats

in Endocrine Connections

Abstract

Low plasma levels of vitamin D causes bone mineral change that can precipitate osteopenia and osteoporosis and could aggravate autoimmune diseases, hypertension and diabetes. The demand for vitamin D supplementation becomes necessary; however, the consumption of vitamin D is not without risks, which its toxicity could have potentially serious consequences related to hypervitaminosis D, such as hypercalcemia and cerebral alterations. Thus, the present study describes the electroencephalographic changes caused by supraphysiological doses of vitamin D in the brain electrical dynamics and the electrocardiographic changes. After 4 days of treatment with vitamin D at a dose of 25,000 IU/kg, the serum calcium levels found were increased in comparison with the control group. The electrocorticogram analysis found a reduction in wave activity in the delta, theta, alpha and beta frequency bands. For ECG was observed changes with shortened QT follow-up, which could be related to serum calcium concentration. This study presented important evidence about the cerebral and cardiac alterations caused by high doses of vitamin D, indicating valuable parameters in the screening and decision-making process for diagnosing patients with symptoms suggestive of intoxication.

Keywords: hypercalcemia; vitamin D; brainwaves; electrocardiogram

Freely accessible including PDF download here:

ec.bioscientifica.com/view/...

[userotc]

It's hard to imagine anyone taking the 4-day dosage indicated which I estimate at ~1.75m iu for a body weight of 10st! If deficient, doctors prescribe high doses but not anything so high.

[helvella Administrator Thyroid UK in reply to userotc]

Except there is a paper which discusses doses of 100,000 IU (monthly) up to 300,000 IU (annually) - which is equivalent to at least 25,000 IU (daily) for at least four days.

Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures

ncbi.nlm.nih.gov/labs/pmc/a...

[userotc in reply to helvella]

OK but even 25k/dy (if correct) is much, much less than my earlier estimate of the relevant super-mega dose (if correct). Let me know if my estimate is wrong.

Is your point that mega doses prescribed by GPs may be close to those that could affect brainwave activity? www-spokesman-com.cdn.amppr...

[Jillymo]

I have hypoparathyroidism and prescribed 250ng x 3 daily.

I've suffered heart failure and showing changes onmy brain scans !

Thanks for posting that artical.