A new drug for thyroid replacement therapy ‘Euthroid’?

[Levo50]

Hi

I was chatting with my neighbour / friend last night and I recently learnt that his daughter 21 was diagnosed hypothyroid 3 years ago, I asked what meds she takes and he said Euthroid?

The family have lived in turkey until 2019 when the marriage broke down, his Turkish wife is a pharmacist in Turkey, not sure if this is relevant but worth a mention.

Interested in any information as when I googled I found ‘A New drug for thyroid replacement therapy’ not sure how old this article is pubmed.ncbi.nlm.nih.gov/414...

[Hidden]

Maybe there is a drug called Euthroid although I have never heard of it. Are you sure he did not say Euthyrox/Eutirox?Any new drug would still contain levothyroxine and/or liothyronine as thyroid hormone replacement is the only treatment for hypothyroidism.

[RedApple Administrator]

Levo50, The article you've linked to is dated 1974. I'm guessing this is around the time when various brands of synthetic levothyroxine were first coming onto the market in different countries. Prior to this, most hypothyroid patients would have been treated with desiccated thyroid preparations.

[helvella Administrator Thyroid UK]

Levo50,

From what I can see, the vast majority of occurrences of EUTHROID are typos/misspellings of EUTHYROID.

It was a combination medicine of levothyroxine and liothyronine in a 10:1 ratio - often referred to as Liotrix.

Generic Name

Liotrix

DrugBank Accession Number

DB01583

Background

Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion. It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% of serum T3 is derived from deiodination of T4 in peripheral tissues. Administration of levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone replacement therapy generally offers no therapeutic advantage. In fact, administration of T3 may result in supratherapeutic levels of T3.

AND

Euthroid (Parke, Davis (United States) (discontinued))

go.drugbank.com/drugs/DB01583

However, it appears to be available in Colombia! But this could just be very old information:

EUTHROID 2 Tablet 120 µg+30 µg

Local name: EUTHROID 2 Tablet 120 µg+30 µg

Country: Colombia

Laboratory: Pfizer SA

Route: Oral route

Form: Tablet

ATC: Levothyroxine and liothyronine, associations

www-vademecum-es.translate....

AND, in Turkey, as EUTHROID-2

www-xn----ilalar--yua-net.t...

AND as EUTROID

Levothyroxine/Liothyronine in Argentina, Peru.

Levothyroxine Sodium/Liothyronine Hcl

Levothyroxine sodium/liothyronine sodium in Argentina.

ndrugs.com/?s=eutroid

And this snippet, for interest:

In its investigation

of fraud in the

pharmaceutical

industry, the Civil

Division won its first

conviction of a brand-

name drug maker,

although it has pros-

ecuted numerous

generic drug manu-

facturers before.

Warner Lambert

fraudulently con-

cealed drug stability

data from the Food

and Drug

Administration for a

popular anti-seizure

medication, Dilantin,

as well as for thyroid

medications Euthroid

and Proloid, and an

anti-parkinsonism

drug, Parsidol.

justice.gov/archive/ag/annu...

Hidden RedApple

[Hidden in reply to helvella]

I wonder if that is the same as Thyrolar in the US which was also called Liotrix...? It has not been available for years. From the info above, it would seem it was discontinued because thyroid patients are not supposed to need T3, only T4.

[helvella Administrator Thyroid UK in reply to Hidden]

Yes - Liotrix and Thyrolar are both T4+T3 combinations.

I used to see them mentioned regularly despite having not been available in many years.

[Levo50 in reply to helvella]

helvella

Thank you for this detailed and informative reply, I did expect with the girls mother being a pharmacist in turkey would have done some research assuming she believes the addition of T3 would be beneficial (even if not necessary) - interesting, I will speak to the girl directly when she visits next to try get more detail.

[helvella Administrator Thyroid UK in reply to Levo50]

Feel free to ask anything!

[Levo50 in reply to helvella]

helvella

Thank you so much!

[tattybogle]

ask him to get hold of an empty packet from his daughter to show you .

I wonder if it's really got 120mcg Levo + 30mcg T3 in it ? .... and where they get it from.

[Yeswithasmile in reply to tattybogle]

You can get it. Cynoplus I think. Or at least that’s one I’ve seen. Available from all good overseas chemist lol.

[helvella Administrator Thyroid UK in reply to Yeswithasmile]

There are several combination products. Most are either 4:1 - more or less emulating desiccated thyroid, or 10:1 more or less emulating the perception of the output of a healthy human thyroid.

I am very suspicious of much online information, as I frequently see equivalents identified where one falls into the first ratio camp, and the second into the other ratio camp.

Link to a database of products:

medicinesfaq.com/brand/cyno...

[Yeswithasmile in reply to helvella]

That’s Helvella. I agree about skepticism re: online info. Can’t say I would want to jump in for a combination product anyway. But never say never. I just knew I’d seen it available at one of the online pharmacies I’d been using. Mind you, I have seen an awful lot of stuff available at these outlets and can’t say I’d want to try any of that either!

[Levo50 in reply to Yeswithasmile]

Yeswithasmile

That would make sense as they live in turkey, her mother is a Turkish pharmacist

[Levo50 in reply to tattybogle]

tattybogle

Sounds like it’s a combo, I will speak to her directly when she visits, may be a while but I’ll update!