A tale of two patients with hypersensitivity reactions to levothyroxine

[helvella]

We have had a number of members say that they have been unable tolerate levothyroxine - or liothyronine.

This double case report might be of interest.

A tale of two patients with hypersensitivity reactions to levothyroxine

E Gansert, W Garzon-Siatoya, D Morgenstern-Kaplan, A Gonzalez-Estrada

QJM: An International Journal of Medicine, hcac029, doi.org/10.1093/qjmed/hcac029

Published:

26 January 2022

Case Report

Learning point for clinicians

Confirmed drug hypersensitivity reactions (DHR) secondary to thyroid replacement therapy (TRT) are uncommon. Active or inactive components such as fillers or excipients may be the culprits behind a potential TRT allergy. Categorizing patients with DHR to TRT based on pretest probability might aid in selecting the best approach between drug provocation test and induction of drug tolerance.

Full paper accessible here:

academic.oup.com/qjmed/adva...

[radd]

Thank you for posting hel

[helvella Administrator Thyroid UK in reply to radd]

Am a bit surprised no-one added any comments as the issue appears to affect quite a number of members.

[radd in reply to helvella]

I am sorry you didn't receive a timely response but my answering will move it to the Daily feed for members to re-view 🤣 🤣.

ps - I am surprised too!