Thyroid hormone resistance

[cazlooks]

If I have Thyroid hormone resistance at a cellular level, would my t3 and t4 be 'over range'?

[jimh111]

Resistance to Thyroid Hormone (RTH - this is the 'correct' term determined by a specialist group a few years ago) is a rare genetic condition which presents with elevated fT3, fT4 and a non-suppressed TSH. So, elevated thyroid hormones but a normal or elevated TSH. Looking back at your post from 8 years ago you do not fall into this category and so do not have RTH caused by a mutation of the TRB (thyroid receptor beta) gene.

However, I had RTH caused by endocrine disruption. There are endocrine disrupting chemicals (EDCs) which are structually similar to thyroid hormone and have the capacity in some people to disrupt thyroid binding to receptors. These EDCs tend not to affect blood test results - because if they did they would have been abandoned during animal testing. I go into lots of detail in my website topic ibshypo.com/index.php/acqui... . I suggest you read it and have a three month trial of simeticone which is cheap, safe and available at any chemist. As you are on very high doses of thyroid hormone you should monitor your pulse daily and be ready to reduce your thyroid dose rapidly if your pulse starts to creep up. I found I had a sudden improvement after about a month and needed to drop my liothyronine dose very quickly. Unfortunately, the improvement seems to kick in abruptly rather than being a gradualy steady improvement.

[cazlooks in reply to jimh111]

thank you so much for this, I will read the article, my pulse rate and blood pressure are fine but I have a watch to monitor both, thank you again cx