I'm male with hypothyroidism and take a mixture of T4 and T3. Mostly I have taken this as a single dose 1 hour before breakfast. My ok dose is 150T4 and 15T3. A lot of symptoms go away. However, I think I'm experiencing some symptoms of overmedication, such as persistent joint pain and muscle injuries.
In an attempt to remove the single spike and possibly the symptoms associated with it, I'm trying to break up the T3 between morning and evening. At this stage it is 12T3 morning and 5T3 evening to try to mimic the decreasing T3 production (it totals 17 not 15, but my reason is that the evening dose will lose absorption). Any comment on this split?
My question is, is there any real point in splitting T4 as well as T3? The half life is 5-7 days rather than 24 hours for T3. But I have heard that when it is taken it still spikes in the blood. Is this accurate? I'd rather not overcomplicate things with T4 split, but if people have experienced significant benefit from it, then I should give it a go.
Just saw a few comments asking for blood test results. Here are my last three (have reformatted this again as when saved all spaces are stripped out) :
FT4 - 19.0 (81% through the range)
TSH - 0.08
FT3 - 5.3
Dose - 150 T4 + 15 T3 - 5 weeks
FT4 - 15.0 (29% through the range)
TSH - 0.16
FT3 - 5.6
Dose - 125 Т4 + 20 Т3 - 7 weeks
FT4 - 16.9 (55% through the range)
TSH - 0.21
FT3 - 5.2
Dose - 140 T4 + 15 T3 - 9 weeks
FT4: 12.8 - 20.4
FT3: 4.0 - 6.8
TSH: 0.4 - 3.8
I'm actually thinking to reduce my T4 from 150 currently to 125 or 140 (see first and second rows) as 150 is over 80% of T4 through the range, which might also be contributing to some symptoms as I've heard too much T4 might also be bad.
The problem with the second line where I was on 125T4 and 20T3 is that I felt rubbish even though FT3 was better. I think it was because 20T3 is far too much for my body to take at once. I might try splitting T3 15 morning / 5+ evening and perhaps 140T4 to be over 50% through the range.
Interesting how just a small tweak in T4 creates a large FT4 difference...