Sublingual Levothyroxine?: Hi Has anyone tried... - Thyroid UK

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Sublingual Levothyroxine?

Topaz21 profile image

Hi Has anyone tried dissolving Accord Levothyroxine under tongue please?

4 Replies

Levo is supposed to be swallowed and absorbed in the gut, the molecules are to big for sublingual use.

helvella profile image

Why would you want to do that?

Levothyroxine itself is only very poorly soluble in aqueous solutions.. It is slightly soluble in alkaline solutions but saliva is usually neutral or slightly acidic in which it is almost insoluble.

Topaz21 profile image
Topaz21 in reply to helvella

An American Thyroid specialist Dr Childs on the Internet said some of his patients dissolved it under their tongue & I have digestive issues & bloods show high T4 but I still have hypothyroid symptoms so I wondered whether anyone had tried this

helvella profile image
helvellaAdministrator in reply to Topaz21

There is a lot of scepticism about sublingual thyroid hormones with many questioning whether any can be absorbed in the mouth. And how you separate out oral absorption from swallowing levothyroxine+saliva in order to prove anything.

As I have not seen satisfactory proof, I'll remain unconvinced. But such proof might exist, or might in future be found.

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