Cytokines blocking T3 receptors

[GWParry01]

Hi

Does anyone know anything about infections causing cytokines ( as in the storms) and these blocking cell T3 receptors leading to CFS fibromalgia / aches / stiffness the works please?

[radd]

GWParry01,

Welcome to our forum,

I don't know about cytokines actually blocking T3 receptors but can reduce sensitivity and decrease conversion as can influence the deiodinase enzymes that help our meds work. That's the reasoning behind encouraging low thyroid antibodies when inflammation is high in the body.

Regarding cytokine storms, there's a load of new papers reviewing this at present because of COVID. Any high inflammation can suppress the HPT axis & I think the hypothesis re COVID is any induced hypothyroid state is a temporary condition, and hypothrodism already established without compromised immune conditions is relatively unaffected but the negative effect on the immune state of Hashi sufferers can be longterm.

Also in RA/PA/etc. Hence the sudden increase of ME/CFS or LongCOVID sufferers, as inflammation results from the same cytokines such as interleukin-1, 6 or 17 in all conditions. As usual the medical profession don't hold a lot of interest or credence to these papers.

Have you got thyroid issues?

[GWParry01 in reply to radd]

Hi thanks RaddYes got Lyme disease in 2015 ( now treated) but still get little relapses and cfs symptoms - diagnosed hypo shortly after been on T4 but not working as well now endo waiting for test results ready to prescribe T3 but would prefer more natural solution if I can T3 sounds like big bang !

Endo also ordered blood tests for anti inflammatory bodies mentioned link - since then I have been reading about anti inflammatories want to try red sage /keffir / tumeric/ ground olive leaf etc first if I can - anything else good I can try ?

I was wondering if the antirheumatic drugs might be worth a try first ? They seem very cheap especially when compared to T3 !

[greygoose in reply to GWParry01]

endo waiting for test results ready to prescribe T3 but would prefer more natural solution if I can T3 sounds like big bang !

Ignore anything doctors tell you about T3, they have no idea what they're talking about, they've never taken it! It's not like that at all. But, if you're having problems converting T4 to T3, it will improve just about everything. They like to exaggerate about it to put people off wanting to take it, because they don't understand it - it scares them - and, in the UK, because it's expensive.

Besides, you can't get more natural than a thyroid hormone! Certainly more natural than an antirheumatic drug!

[GWParry01 in reply to greygoose]

Hi Grey Goose thank very much for reply.

In fairness endo (private) quite happy to prescribe T3 it's me that's worried - he says it can cause osteoporosis and ruin your heart if not monitored properly which I don't like the sound of !

I read your thyroid history you've had a right battle with them - glad you found what works.

Regards

[greygoose in reply to GWParry01]

Yup. What works for me is 75 mcg T3 only.

Doctors love to scaremonger, and put the fear of god (themselves) into their patients. You'd have to take an awful lot of T3 for it to increase - just increase, mind you - the risk of osteoporosis and heart problems. The problem with doctors is they don't understand the difference between high FT3 in patients with Grave's, and slightly over-range FT3 in hypo patients taking T3. It's not the same at all! Don't let him scare you. Call his bluff and accept the T3. You wouldn't want to take that much T3 anyway, I can assure you! I've been over-dosed on T3 - although not to the point of affecting my heart and bones - and it's really not pleasant at all! lol

[radd in reply to GWParry01]

GWParry01,

T3 is the ‘natural’ result of your T4 (Levo) being converted. A small subset of people who medicate Levothyroxine lack the good ability to convert due to a common genetic impairment, necessitating the need to medicate T3 alongside their thyroxine.

There are many antioxidants/anti-inflammatorys and you might need to try several before hitting the one/combo that just makes you feel better. Mine is a mix with several others where curcumin takes centre stage.

Lyme can be immensely difficult to erradicate and a potential cause for Hashi & hypothyroidism. Have you had thyroid antibodies tested? Thyroid hormone replacement requires essential co-factors to work well, such as adequate iron, VitB12, folate and Vit D which has its own anti-inflammatory effects. Have you had these tested recently?

T3 is only expensive in the UK. Have you read Why Can’t I Get Better? by Richard Horowitz.

[GWParry01 in reply to radd]

Hi RaddThank very much for reply - I don't have thyroid antibodies so endo decided its a conversion or receptor problem - I've had almost minus TSH figures and top if the range free T4 but Free T3 still struggling.

Had low b12 and folate in the past but seems normal now - I do the vit D supplement like we all should apparently.

I will see if I can get a copy of that book.

Thanks Again