Useful post by an American clinical scientist

[diogenes]

This document is a good analysis of the state of American clinical thyroid science and diagnosis back in 2012-3. It still reverberates strongly today. The paper is downloadable in full when typing into Google:

Hypothyroidism Treatment Policy in the U.S.: A Literature Review

Dorothy Pugh

[helvella]

Interesting to see she has tweeted this:

Dorothy Pugh

🕷️ 🦋 🐦 🐸 🌼 🦀 🐿️ 🦉

@bergamotley

A ground-breaking model, challenging the conventional assumption that #TSH levels vary chaotically while #T4 levels remain stable except in the rare few with "overt" #hypothyroidism. Maximum thyroidal output is used to show the true meanings of these surrogate variables.

twitter.com/bergamotley/sta...

In response to:

Johannes W. Dietrich

@drjwdietrich

Now available in print, too: Our eBook "#Homeostasis and #Allostasis of #Thyroid Function". frontiersin.org/research-to...

doi.org/10.3389/978-2-

twitter.com/drjwdietrich/st...

Follow the link to Twitter if you wish to follow the links. They are broken as they appear here!

[LindaC]

Once more diogenes, thank you so much.

[shaws]

Thanks diogenes.

[tattybogle]

academia.edu/32567635/Hypot...

some snippets i enjoyed;

"When two elephants fight, it's the grass that suffers.-African proverb....."

"when in doubt, make the assumption most likely to do the lesser harm if wrong (or the greater good if right)..."

"L-thyroxine is a hormone essential for life, Actually, the full formal name of this molecule is (S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid ,

..... L-3,3',5,5'-tetraiodothyronine is a somewhat less formal term also used. For the sake of simplicity, I will refer to these molecules by their common names, e.g., thyroxine or its even simpler name, T4. ...." that's a relief

[vocalEK in reply to tattybogle]

And then there was this: "What we need, then, is a better-coordinated approach to patients with hypothyroidism aimed at understanding the whole problem, perhaps with fresh eyes, giving reduced weight to studies that include unproven assumptions in the starting points of their reasoning. "