Am I allowed to post this research paper?

[Jenny583]

Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment

Carlos E Fardella 1 , Rocío A Artigas, Sergio Gloger, Marcela Jiménez, Cristian A Carvajal, Paola M Krall, Danilo Quiroz, Carmen Campino, Lorena M Mosso

Affiliations

PMID: 17906375 DOI: 10.1007/s12020-007-0042-7

Abstract

We here described a 39-year-old woman with a severe chronic mood disorder, refractory to antidepressive therapy who showed a significant improvement after a self-prescription of high doses of liothyronine (T(3)). A modified Refetoff protocol was carried out to study the role of thyroid hormones on her clinical and biochemical responses. Depression severity was assessed by the HAM-D and MADRS Depression Rating Scales. Sequencing of Thyroid Receptors (TR) alpha1 and beta1 genes was done. At the final stage of the study, plasma T3 and free T3 were >800 ng/dl (80-180) and 1409 pg/dl (230-420), respectively. No changes in the cardiovascular parameters, alkaline phosphatase isoenzymes, creatinine kinase, or ferritin were observed. However, an improvement in mood was detected by specific scores (HAM-D 24 to 8; MADRS 40 to 11). No mutations in DNA- and hormone-binding-domains of TRbeta1 and TRalpha1 genes were found in proband, suggesting that the defect could be due to an unknown mutation in either the TR gene or a post receptor abnormality. These results support the existence of a peripheral RTH manifestation as a refractory chronic depression reverted by high doses of T(3). Screening for RTH in refractory chronic depression may provide an alternative treatment for this psychiatric condition.

pubmed.ncbi.nlm.nih.gov/179...

(Admin added text of abstract.)

[helvella Administrator]

What I usually do is post the abstract. The paper is behind a paywall and it would not be appropriate to post the full paper. Have a look at my profile and you will find many posts about many papers.

We also ask that if you post links, you should identify what the link points at. Like the title of the paper. Helps people decide whether your link is trustworthy, and if it might interest them.

[Jenny583 in reply to helvella]

Thanks h, I nearly did that, But a dire warning came up as I was about to post. At least I know the link works on the abstracts. I will leave links to the experts from now on.

[helvella Administrator in reply to Jenny583]

The dire warning is simply that - a warning. That what you are posting contains a link or an email address. It is just trying to protect you. You can ignore it.

[greygoose]

What is it research into? Could you tell us what it's about and why you posted it?

[Jenny583 in reply to greygoose]

The research behind the abstract is about thyroid hormone resistance, & it's effects on mood disorders. Many people are put on anti depressants that do not work. This paper highlights the case of 1 woman that was helped by Liothyronine. I have seen historical references to the fact that many were helped by T3 - for a while, in the 20th century, but then pharma muscled in & stopped it. I lost a friend this year to this type of thyroid disorder.

[greygoose in reply to Jenny583]

Oh, that's interesting. Thank you for posting.

Sorry for your loss.

[DippyDame]

Thank you....the abstract and following links are useful.

Do you have a type of RTH?

Why did you post this?

Would be a good idea to edit your post and give members some background, not everyone will open a link with no info attached....and may miss something of interest.

[Jenny583 in reply to DippyDame]

I didn't think the link would work. New to all this. I know better now. Thanks for the tip.