Second call for participants in Graves' disease... - Thyroid UK

Thyroid UK

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Second call for participants in Graves' disease study

lynmynott profile image

Thyroid UK has been approached again about a clinical trial investigating a new drug for Graves’ disease and wondered if you or anyone else you know might be interested in taking part. This trial was put on hold due to the COVID-19 pandemic restrictions but has now resumed recruitment, with safety considerations for hospital staff and patients.

This phase I study is investigating a potential new drug, K1-70, to treat patients who have Graves’ disease, thyroid cancer, and patients who would benefit from controlling thyroid stimulating hormone receptor (TSHR) activity.

A Safety Review Committee found the drug to have been safe and well-tolerated in the patients treated so far. A further 3 patients with Graves’ disease are needed to complete this study.

Travel to and from the study site in Manchester is provided from a patient’s chosen location, as well as accommodation for patients travelling from far, with safety measures in place.

If you would like some more information or are interested in taking part please contact the Volunteer Services team at the Medicines Evaluation Unit on 0800 655 6553 and quote “study MEU 15/304”.

They will be able to answer any questions you may have and book you in for a more in-depth discussion.

5 Replies

Hi is this proven to do anything because my doctor thinks I have Graves’ disease or hyperthyroidism but not 100% sure because I don’t have all the symptoms of Graves, however I am overactive and been on medication for a year my symptoms have balanced and don’t feel as bad as I did, possible try?

helvella profile image
helvellaAdministrator in reply to Beau005

If I were you, I'd send my details to the people conducting the trial.

They are the only ones who really know whether you would be a candidate.

Beau005 profile image
Beau005 in reply to helvella


pennyannie profile image
pennyannie in reply to Beau005

Hello Beau

I've just seen your post from 2 months ago :

There is an antibody blood test that can be run to diagnose from if you have Graves Disease.

You need to be over range for the TSI ( roughly translated as a thyroid stimulating ) and or the TR ab ( rough translation is of a thyroid blocking ) antibodies and this should have been run before you were prescribed medication.

You might like to read up around thyroid autoimmune conditions on the Thyroid uk website, who are the charity who support this amazing forum.

Should you have Graves I found the Elaine Moore Graves Disease Foundation website a most useful adjunct to this forum.

Hello, do you happen to know if the intake is still available for this trial?

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