Bianco and co workers have developed a T3 derivative that has much better retention and pharmacokinetics than T3 alone. That is, it doesn't "spike" as much after giving it, and lasts longer. The study is in rats as it has to be at first, but it looks as if it might be possible to produce a T3 compound that is less likely to harm and better for intake and use in humans.
METAL COORDINATED POLY-ZINC-LIOTHYRONINE PROVIDES STABLE
CIRCULATING T3 LEVELS IN HYPOTHYROID RATS
Rodrigo R. Da Conceição 1,*, Gustavo W. Fernandes2,*, Tatiana L. Fonseca, Antonio Bianco2
The paper is available to download until the end of October