Unreliability of previous trials of combination... - Thyroid UK

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Unreliability of previous trials of combination therapy

penny profile image
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This may have been posted here some time ago but I came across this when looking at a trial currently being carried out in Greece as the the effectiveness of using T3 to treat Covid-19. (I also came across a trial of T3 for treating MS where T3 showed no adverse effects.)

It seems to be saying that previous RCTs were flawed and conclusions that T4/T3 therapy is no better than T4 monotherapy should not be used in treatment as this is not correct.

hindawi.com/journals/jtr/20...

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penny profile image
penny
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tattybogle profile image
tattybogle

Yes they were /and mostly continue to be, flawed.

I assume this is explained by deliberate closed eyes and ears.

Our 'diogenes' is one of the authors in the paper above , so he knows better.

But you need to inspect the funding and motivations of most trials of combination therapy, a proven finding that levo alone doesn't always work will not be welcome by many wishing to maintain the status quo. So it's in their interests to support, and quote evidence from trials that are set up with parameters that include people who are unlikely to benefit, exclude people who may benefit, and use dosages/timescales that are incorrect , and so unlikely to give improved outcomes in participants.

And it's in their interest's to remain conveniently blind to any better trials, and obstruct funding or publication and acknowledgement of them.

penny profile image
penny

I apologise to you and Diogenes for being behind the curve, as usual.

tattybogle profile image
tattybogle in reply topenny

Aw! don't beat yourself up penny :)

i see you got your medical notes 6 yrs ago, so you are ahead of the curve on that one at least .I've been hypo for 17 yrs and only got mine in February ! , and also i've only just learned how to copy and paste , thanks to help from here :)

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