Effects of chronic levels of T2

[diogenes]

This paper using rats shows that T2 in substantial amounts can both stimulate body metabolism and also exert an effect on the pituitary to give central hypothyroidism. No doubt we humans never achieve that level of T2 but the paper serves as a warning over too much T2 in the body. It's open access

Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and

stimulates thyroid-sensitive tissues

Alvaro Souto Padron, Ruy Andrade Louzada Neto, Thiago Urgal Pantalea, Maria Carolina de Souza dos Santos, Renata Lopes Araujo, Bruno Moulin de Andrade, Monique da Silva Leandro, Joa˜o Pedro Saar Werneck de Castro, Andrea Claudia Freitas Ferreira and Denise Pires de Carvalho

joe.endocrinology-journals.org

DOI: 10.1530/JOE-13-0502

[TSH110]

This looks like a direct link to the article: joe.bioscientifica.com/down...

[tattybogle]

Very interesting, especially the bits about diiodinase's. Thankyou diogenes.

Although , as usual, i got boggley eyes and a headache just when it was getting interesting.

And then i start feeling sorry for the rats. I'd happily offer myself up for experimentation with thyroid hormones , (or even bits of thyroid hormones !) and let the furry ones retire.

But no one will give us any