This is an downloadable abstract (full text not available so far) describing what T2 does and how it responds to different situations. Very academic but is interesting.
Front. Endocrinol. | doi: 10.3389/fendo.2019.00787
3,5-T2 – A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine And Intracrine Hepatic Action
Josef Köhrle, Ina Lehmphul, Maik Pietzner, Kostja Renko, Eddy Rijntjes, Keith Richards, João Anselmo, Mark Danielsen and Jacqueline Jonklaas
Link to this abstract: frontiersin.org/articles/10...
I also found the following under the same above link: "..1 week after MI ameliorated heart performance without reversing cardiac remodeling (163). By contrast, THs administered early after IR enhanced cardiac function and prevented left ventricle remodeling (116, 121, 122, 164, 165). These finding are in line with the key role of T3 as main modulator of cardiac repair/regeneration, a process that is critically affected by dynamic epigenetic mechanisms. As for other cardiac epigenetic regulators, such as plant compounds or selected exosomes (166, 167), lower T3 doses proved more efficacious than pharmacological treatments in contrasting the noxious pathways of adverse remodeling (168, 169). Such information on optimized dose and timing for T3 delivery after IR should provide clinically translatable protocol based on inexpensive, commercially available T3."
which shows yet again the importance of t3.
Interesting, are you able to interpret it a bit please?
What could be the coffee implication?
Thank you! (On a lighter note, that 'Keith Richards' is still getting 'round 
)
Who is that?
A Rolling Stone !
I never liked them. The Beatles were ok till that Maharishi fellow came along and they went weird
Someone who has, against all odds, still survived 
I think it was the Beach Boys who got 'round.
Are they saying that coffee is stripping/leeching T2 out of the body? Also, are they saying they don't think T2 is a metabolite of T4? And that it might be a metabolite with an equal production to say, T4.
A lot of this is going to need further studies as it flies in the face of what, hitherto, we have understood.
What they are saying first of all is that up to now, measurement of T2 by the usual methods has fallen far short of acceptable. T2 is certainly produced in low amounts compared with T4 and T3 say, but just because it is nearly absent in serum doesn't mean that in some specific organs or organelles like mitochondria (where it is active) the T2 levels aren't quite high. Why T2 is raised in nonthyroidal illnesses I cannot say and nor can they. The whole of the T2 story is "up in the air" and first, the measurment methods have to become acceptable and second, the exact aims of T2 in controlling body metabolism is still to be discovered.
"However, the unexpected association between high serum 3,5-T2 and elevated urinary concentrations of metabolites related to coffee consumption requires further studies for an explanation."
So people with extra T2 wee out more breakdown products of coffee?
Might that mean their liver is more efficient at clearing coffee from the body?
I know the researchers don't know either but seems like a possible hypothesis
Just read the rest of it. High T2 in the blood is associated with serious illness, especially kidney failure. So my hypothesis seems unlikely. Unless high blood T2 is the body's last ditch attempt to compensate or correct kidney failure???
I once read that when someone has just died, cells in some tissues (brain if I remember) reverted to stem cells. Maybe trying to restore the dying tissue.
Wow, that's deep.
So many intriguing questions!
Would this be another reason to return to NDT for those of us without a thyroid?
Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression ParadigmsNew review showing how T2 works
What does a GOOD thyroid result look like?What does subclinical hypothyroidism mean and should it be thought of as a disease and does using TSH as a diagnostic confuse diagnosis?
What does T4 do?
