Tania Smith's visitation on equivalence of DTE (NDT) and T4 in dosage

[diogenes]

It's often discussed on this forum what is the equivalence in dose effect of NDT and T4. Tania Smith's latest blog discusses this and sets out a table of conversion which the forum will find useful.

[stiltzski]

Could you attach a link please? I can’t find it by googling for some reason...

[helvella Administrator Thyroid UK in reply to stiltzski]

Certainly:

thyroidpatients.ca/2020/05/...

I suspect it is simply too new and the search engines haven't yet indexed it.

[TSH110 in reply to helvella]

It is up there came in to me at 10:38 this morning to my inbox & link all fine

[stiltzski in reply to helvella]

Thanks very much.

[TSH110 in reply to stiltzski]

Always put in - Dr Tania Smith thyroid - and you should get the home blog page linking to all her articles in date order from most recent, you can get email alerts set up, though I know they are not for everyone

[humanbean]

For example, the ATA decried Hoang’s failure to measure the “excursion” of T3 concentration potentially above reference 3 hours after a large DTE dose. Yet the ATA authors admitted that “The clinical consequences of such serum T3 excursions are unknown.”

What does "excursion" mean in this context? The thing being measured goes out of range? or is it specifically over the range?

[diogenes Remembering in reply to humanbean]

It means in real language that taking T3 gives a short-lived spike in blood FT3 over the top of the reference range, shading down into normality soon after. It probably doesn't matter, being relatively short in duration. And the spike's metabolic effects will be slow to show themselves if indeed they do, because the effects won't have time to kick in before the FT3 has returned to normal. This is called a damped response.

[humanbean in reply to diogenes]

Thank you.

[jimh111 in reply to diogenes]

When on high doses of L-T3 (up to 105 mcg daily, half am half bedtime) I monitored my pulse overnight. Although my pulse was higher than normal (~80 v ~72) I had no variation of pulse rate overnight. i.e. the fT3/tT3 spike that occurs approx 3 hours after L-T3 ingestion had no effect on my heart rate.

[UrsaP]

Thank you for pointing this out