DNA test

[kluang]

I am letting people know that the Ancestry test is on sale now at £49. I believe that the test raw data includes the test for DIO1 and DIO2 if anybody is needing this.

For DIO1 the rs numbers are rs2235544 and rs11206244. A normal result will be a C or G, and the mutation will be T or A

For DIO2 it is rs225014 and normal is T or A and the mutation is C or G

23andme do the DIO1 but of recent times the DIO2 has been removed. If you have an old test the raw data might just have it on.

[galathea]

Brilliant. People don't seem to know that once you have had a test, you can download your raw data and keep it. Then when you want to investigate a particular gene, there are several websites where you can upload your data geneticlifehacks is one of them and check the various genes. Its also possible to check for yourself if you are good with spreadsheets.

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[SlowDragon Administrator in reply to galathea]

How very, very interesting

Is it easy to download the data.....?

I was given this test as a gift...as I really like family history.

Only just got the results this week. So not explored it all yet . But was wondering the other day if it gives the raw data..

I already know I have DIO2

But would be interested in finding Dio1

Can you check these ones too? - (from Blue Horizon DNA test)

COMT - Inactivation of Stress Hormones and Oestrogen

COMT is one of the main inactivating enzymes of stress hormones and oestrogen in the body. COMT variants cause slow clearance of stress hormones and oestrogen leading to high oestrogen and stress hormone levels which may also be linked to thyroid hormone dysfunction.

FKBP5 - Cortisol Regulation

FKBP5 is an important stress-regulating gene responsible for lowering cortisol levels after a stress response. Variants are associated with prolonged and increased symptoms of stress, which may be due to delayed lowering of cortisol levels.

PDE8B - TSH Signalling

PDE8B is found in the thyroid but not the pituitary, and is involved in TSH signalling. It is thought that the variant decreases the response of the thyroid gland to TSH stimulation

TNF-a - Inflammation

TNF-a is an inflammatory cytokine that helps regulate the immune reaction involved in inflammation, giving rise to fever and inhibiting tumour growth. If poorly controlled, it may be implicated in a number of autoimmune disorders. Variants in TNFa are associated with overreactive immune responses and prolonged inflammation.

TSHR - Thyroid Stimulating Hormone (TSH) Receptor

The TSHR gene plays a central role in thyroid metabolism by controlling the thyroid gland’s receptivity to TSH. Variants in this gene have been linked to hyperthyroidism, particularly to Graves’ Disease (GD).

TRHR - Thyrotropin Releasing Hormone (TRH) Receptor

Responsible for the body’s receptivity to TRH which stimulates the secretion of TSH from the pituitary gland. In turn, TSH stimulates the production of thyroid hormones from the thyroid gland. TRH is an important part of the negative feedback loop that ultimately regulates thyroid hormone levels. Variants have been shown to affect TSH levels.

Also vitamin D polymorphism and MTHFR

[Hibs1 in reply to SlowDragon]

I was given that as a gift last year but included both of the tests. The family info was spot on with what my dad and brother had found out.

To tell you the truth I was rather disappointed with the health parts as didn't really say much. But said I wasn't likely to be lactose intolerant when I am. I just left it sitting in my inbox. I wouldn't know how to do anything with it sounds all too complicated for me😧

[galathea in reply to SlowDragon]

You just go to the website of whoever has done your test and type. Raw data in the search box, the give your email address and the raw data is sent as a zip file..

I certainly found that i had mthfr problems from searching the raw data. I put the data into a site that specifically looked for the gene. You will have to do a few searches to find which sites are looking for the other genes you mention.

Ihavent paid for the checks i have done but there are a lot of sites that want you to pay.

Here are some free ones...

geneticlifehacks.com/cheats...

xcode.life

(Not free but they give you enough information for you to check for yourself if you can use a spreadsheet)

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[thyroidmom84]

Thank you for this!

[TaraJR]

I've just received my Ancestry results. But all I can find so far is how many DNA matches I have via Ancestry eg cousins, and percentages of my ancestry eg 81% England Wales & NW Europe.

Where do I find my raw data?!

[galathea in reply to TaraJR]

Goto the ancestry site and type raw data into their search box

[MichelleHarris]

TaraJR I didnt know this either. But if you have a look at the bottom of the page on Ancestry DNA there is a bit about downloading your DNA via email but they say the Data security is not there responsibility then x

[galathea]

No it’s not their responsibility if you have your data and upload it to different sites. I don't mind doing this, but i know that the sites do compile lists from the data, with the aim of connecting up to people who make meds..... one of the testing labs does this too.

The worst that can happen is that someone might decide to clone me.... wow! I would be seriously impressed!