Hypo and Hyper. 2 sides of the same disease

[asiatic]

2 points came up in recent posts.

1. Moving from Hashi to Graves.

2. TSH receptor sites in the body.

The following papers address these points :-

dx.doi.org/10.1155/2012/182176

ncbi.nlm.nih.gov/m/pubmed/2...

What I take from 1 Is TRAb is found in both autoimmune hypo and Graves.

TRAb ( measured as TBII) reflects a mix of both blocking antibodies ( TSBAb ) and stimulating antibodies ( TSAb / TSI ) which cause Graves hyperthyroidism. Which antibody dominates can change. 2 patients from the hypo group developed Graves and 2 from Graves group became hypo. The conclusion was both autoimmune hypo and hyper diseases are 2 sides of the same disease - TRAb Disease.

Paper2 suggests we have TSH receptors not only on our thyroid but on Pituitary, skin, kidney, orbital fibroblasts, bone, ovary, testes, and from another paper the heart.

Could some of you knowledgeable people comment on these papers. I find them interesting but don't fully understand them. Eg I didn't think patients recovered from Hashi as suggested. Also can TSH receptor sites being so widespread throughout the body explain our widespread symptoms.

I hope people will comment.

[DeeD123]

Thank you . Will have to read tomorrow as my eyes won’t let me do it this time of night.

[Nanaedake]

I'm unsure what the paper means by 'recover'. I've certainly seen people who have raised TSH and raised TPO antibodies that normalise. However, whether this is temporary or a permanent recovery is unknown to me because I would have to find out in 20 years time or so whether they are still disease free. I don't know whether scientific research has been conducted to find out?