Looking for Articles

[Portia1974]

Hi there

Am looking for a couple of articles that I recall reading but cannot now track down.

One explains why a suppressed TSH is not problematic if it means ft4/ft3 is optimal and what constitutes "a Euthyroid state"

The other is about the the optimal/desired place for FT4/FT3 to fall within the range. I have heard that FT4 should ideally be a minimum of 70% into range.....and FT3 a minimum of 50% into range. Can anyone direct me to the source of that assertion? What is it based on? A research paper, an opionion of a well regarded Thyroid specialist or organisation.

Ring any bells with anyone? Can anyone direct me to reputable source that I can hit my GP with please?

[diogenes Remembering]

As a start these may help:

Ito, M., Miyauchi, A., Hisakado, M., Yoshioka, W., Ide, A., Kudo, T., … Amino, N. (2017). Biochemical Markers Reflecting Thyroid Function in Athyreotic Patients on Levothyroxine Monotherapy. Thyroid, 27(4), 484–490. doi.org/10.1089/thy.2016.0426

Ito, M., Miyauchi, A., Hisakado, M., Yoshioka, W., Kudo, T., Nishihara, E., … Nakamura, H. (2019). Thyroid function related symptoms during levothyroxine monotherapy in athyreotic patients. Endocrine Journal. doi.org/10.1507/endocrj.EJ1...

Ito, M., Miyauchi, A., Morita, S., Kudo, T., Nishihara, E., Kihara, M., … Amino, N. (2012). TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy. European Journal of Endocrinology, 167, 373–378. doi.org/DOI: 10.1530/EJE-11-1029

[Portia1974 in reply to diogenes]

Thank you. Have taken a look and these are a bit beyond me I'm afraid. (The last one doesn't work for me) Plus I haven't had a total thyroidectomy so would these still relate? The articles I'm thinking of were by a Prof that was much revered on here and from what J can gather had now passed away. But for the life of me can't remember his name. Ring any bells? He used to be heavily quoted on here and the Thyroid UK site itself.

[diogenes Remembering]

And this one:

Front. Endocrinol., 22 December 2017 | doi.org/10.3389/fendo.2017....

Recent Advances in Thyroid Hormone Regulation: Toward a New Paradigm for Optimal Diagnosis and Treatment

Rudolf Hoermann1*, John E. M. Midgley2, Rolf Larisch1 and Johannes W. Dietrich3,4,5

[Portia1974 in reply to diogenes]

Thank you so much! That should keep me quiet for a bit!

[diogenes Remembering]

I think you are looking for Dr Lowe. TUK has several articles of his in archive.

[Portia1974 in reply to diogenes]

Ah yes! That rings a bell...thank you! Possibly Dr Skinner or Peatfield too? I can't seem to find it on Thyroid UK though.

[Gingernut44 in reply to Portia1974]

Also look for Dr Anthony Toft - article in Pulse Magazine and also his "Counterblast" to Thyroid replacement therapy

[Portia1974 in reply to Gingernut44]

Do you know...I think that might be it!!!

[Gingernut44 in reply to Portia1974]

I hope you can find them - I can't find the links but I have printed them out and handed them to my Doctor. Good luck

[Portia1974 in reply to Gingernut44]

Yep found it. Thank you so much!