A Systematic Review and Meta-Analysis of Patient Preferences for Combination Thyroid Hormone Treatment for Hypothyroidism

[jimh111]

Not even glanced at this yet but it seems to be another nonsense meta-analysis of studies using the wrong cohorts and treatment options. Complex analysis applied to bad data. GIGO.

frontiersin.org/articles/10...

[Aunds]

Hi jimh111, thank you for posting and there was at least a positive suggestion in the conclusion

“ L-T3 and L-T4 therapy compared to L-T4 alone; this finding was not distinguishable from chance. An observed potential positive L-T3 dose effect on treatment preference deserves further study“

[jimh111 in reply to Aunds]

It's a feeble response after a lot of effort and money (not ours) was wasted. These studies need to be driven by the data, selecting patients who need T3 and determining what dose they need, as opposed to the current regime where they demand patients respond according to their hypothesis.

[Greekchick in reply to jimh111]

I have read this paper myself, and one of the Canadian authors at McMaster University also is an author on the Pilon study about clinical subhyothyroidism - and that study was recently criticized by one of the British thyroid medical associations - I suspect this Canadian author has political reasons for wanting to push the T4 agenda. I can't prove it - but I suspect it. And you are correct, this author has used specious data and meta-analyses are fraught with methodological problems. Selection of data in this case is very problematic.