Another Greenmed Info article. It's mainly a study on Hashimoto's treatment (effective results) with Black Seed Oil. But it also offers an in-depth discussion of the molecular inadequacies of T-4. greenmedinfo.com/blog/black...
This article is almost 2 years old, but still very timely.
Afraid the graphics and "explanation" of why synthetic T4 (and T3) are not bio-identical is woeful.
Showing the tiny T4 and T3 against the huge (mis-spelled) thyroglobulin does show the difference between the thyroid hormone bound within desiccated thyroid.
But in a healthy person, thyroglobulin remains inside the thyroid. T4 and T3 are released by the thyroid into the bloodstream and then bind to thyroid binding globulin (and transthyretin and albumin).
I believe that this binding is exactly what also happens to the synthetic T4 and T3 we take orally. They are absorbed and enters the bloodstream - then bind to thyroid binding globulin (and transthyretin and albumin).
He says: while the primary structure of amino acids in synthetic thyroxine produced from genetically modified yeast is virtually identical to that produced by the human thyroid gland, the secondary, tertiary and quaternary folding patterns of that protein may differ in significant ways.
But T4 and T3 (as sort-of implied) are NOT proteins.
I am not aware of anyone, anywhere, who has managed to distinguish between synthetic and non-synthetic T4 and T3 once in the bloodstream. (I have no issue with considering why people find differences in how they feel depending on source. But you really don't have to go into what seem to me to be misrepresentations of conformational states.
Black seed (Nigella sativa) may well be wonderful. 
Another half-cocked pseudo explanation of thyroid problems to confuse the reader. One needs a much better organised clinical trial to find out whether nigella sativa seeds work or not, how and when and with what response. Placebo controls also have to be done. Until then this is just a supposition out of thin air.
The real trouble with all these "witch-doctor" sites is that they correctly identify the need for combination T4/T3 therapy in the appropriate cases, but propose the most absurd "yallery-greenery" pseudo-explanations as to why T4 alone can be suboptimal. What I worry most about is that our group's work, which describes physiological workings of the thyroid and the body in this respect, and uses hard science to justify conclusions, is being hijacked indirectly by these people. This linkage, however accidental, nevertheless puts us in the eyes of the naysayers into their camp. This makes our studies then put under a cloud by association, promoting automatic denial and refusal to engage. They have to be quashed wherever they emerge, but they do irreparable damage to the right cause, in my opinion.
Why do so many people post questions/comments for members only? What is the point?
Are you adding t3 to NDT? Why and does it work for you?
Black cumin for hypothyroidism and Hashi's?
Black Seed helpful for Thyroid function
