T3

[Yazz1]

I've been reading up on Dr Wilson's Temperature syndrome he explains everything around T3 and even offers to speak to your doctors for free.

[BlueMoon65]

Just found this, and will follow up! Looks like the answer to a prayer for me! Just off to get another blood test, and am being referred to cardio. Will get onto this information pdq! Thank you!

[shaws Administrator in reply to BlueMoon65]

See my response below to Yazz1

[shaws Administrator]

One of our Advisers, also a scientist and researcheer, and an expert on T3 stated the following:-

"Dr. Wilson has it backward: T3 doesn’t Increase enzyme activity by raising the body temperature; instead, it’s the other way around: T3 increases gene transcription for enzymes (such as sodium-potassium-ATPase), and the resulting increased enzyme activity raises the body temperature. The enzymes do this by cleaving phosphates off ATP molecules. The cleaving releases the energy that was maintaining the phosphate bonds. About half the energy is used to fuel chemical reactions. The other half is released as body heat.

This may seem trifling, and indeed, the issue of which comes first, increased temperature or enzyme activity, may only be an academic concern. But other issues I believe Dr. Wilson gets wrong have practical implications. For example, I don’t believe sustained-release T3 is the best use of T3. The reason? The longer T3 stays in the small intestine, the greater the chance that calcium and other agents in food will bind some of the T3. The binding will then carry the T3 out in the patient’s stool, reducing the amount that reaches his blood."

web.archive.org/web/2010103...

[helvella Administrator in reply to shaws]

A little on how body temperature is maintained:

Maintaining body temperature

The first uncoupling protein discovered, UCP1, was discovered in the brown adipose tissues of hibernators and small rodents, which provide non-shivering heat to these animals.[2] These brown adipose tissues are essential to maintaining the body temperature of small rodents, and studies with (UCP1)-knockout mice show that these tissues do not function correctly without functioning uncoupling proteins.[2] In fact, these studies revealed that cold-acclimation is not possible for these knockout mice, indicating that UCP1 is an essential driver of heat production in these brown adipose tissues.[6][7]

Elsewhere in the body, uncoupling protein activities are known to affect the temperature in micro-environments.[8][9] This is believed to affect other proteins' activity in these regions, though work is still required to determine the true consequences of uncoupling-induced temperature gradients within cells.[8]

en.wikipedia.org/wiki/Uncou...

[shaws Administrator in reply to helvella]

Thanks helvella

[diogenes Remembering]

In this paper, a single dose of T3 raised body temperature by about 1 degree C which lasted for some time in volunteers. So T3 may have some effect but not a large one.

Ther Drug Monit. 2015 Feb; 37(1): 110–118.

doi: 10.1097/FTD.0000000000000113

PMCID: PMC5167556

NIHMSID: NIHMS835764

PMID: 24977379

Single Dose T3 Administration: Kinetics and Effects on Biochemical and Physiologic Parameters

Jacqueline Jonklaas, MD, PhD Kenneth D. Burman, MD, Hong Wang, MD, and Keith R. Latham, PhD

[Judithdalston in reply to diogenes]

A single T3 dose raises temp. by 1 degree C ...presumably in healthy volunteers, but not hypos who have struggled on levo.? I have been using basal temperature ( mercury thermometer by mouth, not armpit) as well as bp/ pulse to try to see how my adding T3 to levo. dose was progressing...so not a single dose but going up to 50 mcg T3 on top of 100 mcg levo. and have occasionally got a raise in temperature of 0.4 C from levo. dose only but much more commonly 0.2C to 35.9-36C . I’ve got to the point after nearly a year introducing the T3 when I have to assume I will not get any further increase and have to continue with outdoor winter underwear even in these rising Spring temperatures...any comment? I do have hypo, Hashi and also fibromyalgia; I’ve now just put my levo. dose up, and reduced T3

[shaws Administrator in reply to Judithdalston]

One of our deceased advisers was an expert in the use of T3. I shall give you a link which may be of interest. The dose of T3 must be high enough to relieve symptoms but you must always be aware of your clinical symptoms which should begin to be relieved. This is also from the Adviser who was an expert in the use of T3 as he himself took 150mcg of T3 daily because of 'thyroid hormone resistance'. Read 'safely getting well'.

This is just for info:

naturalthyroidsolutions.com...

web.archive.org/web/2010103...

[Judithdalston in reply to shaws]

Yes , I know of Dr Lowe’s archive, Q&As on Thyroid U.K. archive....like the new presentation ... might find something new in it. Old documents were not that easy to read with lots of typos and odd format. Thanks