I'm on 50mg levothyroxine. My TSH was 5.5 and T4 11 when I started it in November. I'd been feeling really exhausted and been gaining weight, with some other symptoms. I have ongoing issues with anxiety and occasional panic attacks. I changed my SSRI from citalopram to sertraline after reducing my citalopram dosage to 5mg and it not working out in oct. Initially 50mg of sertraline made my anxiety much better but its slowly become worse. My dose of sertraline has been upped to 100mg and I am a bit better but still feel an underlying anxiety. I wondered if anyone else has experience of this? I know anxiety can be a side effect of levothyroxine. I thought this might be just if you're on too high a dose? I'd appreciate any experiences as I don't really feel like my GP has time to explore these things in appointments.