DNA Blue, Genetic Thyroid test. Thoughts?

[FancyPants54]

This test is offered by Blue Horizon. Has anyone had it? Was it helpful? It seems to cover D102 gene issues and lots more.

[Naomi8]

Posted my sample on Monday(5th)still awaiting results

[Angel_of_the_North]

Did it. Not sure it was worth it. See previous threads on this subject.

[silverfox7]

I e not had that test but I understand it is expensive so it might be better getting all the more basic tests (I get mine done at the hospital so not aware of the best ones but if you ask I'm sure someone will advise). as with comments when you post them it might note suggest a faulty gene but a conversion issue for example or just not on enough medication. When all else fails then that may be your problem but I would look at other things first.

[DippyDame]

I had it done, mainly for personal interest - I had gone down T4 mono therapy route for about 20 years with no success and GPs offered nothing else so I wanted to explore further possibilities....with the amazing help and support from other members.

I was pleased with the results but haven't discussed it with my GP so far. In today's T3 climate, and amongst the deniers, I doubt it will hold much sway. But...you may find otherwise!

I self medicate with T3 and buy my own supply ( not so easily done now) The test verified poor conversion due to the DIO2 polymorphism which I inherited from both parents ( considerably increases the problem!) and helped explain decades of declining health and indicated what I needed to do to improve my health....this is now happening!

Firstly, are you sure you are inadequately medicated on levo...the test will not indicate that.

Best...

DD

[FancyPants54 in reply to DippyDame]

I was mainly looking at it wondering if it would help to know the outcome of the D102 gene test. I've decided against it for now and just ordered the normal TSH, FT4 and FT3 test as I need to check my latest dose.

I think I'm going to need T3 adding. I'm just not getting much response from Levo on it's own. I am very worried about that as supplies abroad seem to be drying up from what I see on here, and I doubt I'd get any out of my GP. Perhaps the endo. would consider it, but I think not. So for now I'd best keep going with Levo and see if another raise might get me closer. I will check back in here with my latest results when I get them. I can't work out how to work out the conversion rate, but someone here will be able to help me with that I'm sure.

[DippyDame]

Post your test results and someone will advise. It should be possible to get an idea of how well you convert from the results. Greygoose gives good advice on this.

A very rough guide would be-

high T4/low T3 suggests poor conversion

Poor conversion may not always suggest a need for added T3 it might be the result of poor nutrient levels. Have you had Folate Ferritin, Vit B12 and Vit D tested? These all need to be at optimal level - not just in range - in order to support conversion. This needs to be addressed and tested before adding T3.

I think you are wise to start with hormone tests and leave the genetic test meantime. Consider nutrient testing next.

In my experience you will receive better advice here than from most medics....who are generally clueless about thyroid hormones!

Good luck

DD

[helvella Administrator Thyroid UK]

For clarity, the gene that affects T4 to T3 conversion is called DIO2 - that is, three letters and a number. Not D102 - a letter and three numbers.

The name comes from the enzyme that this gene affects which is a deiodinase. It removes an iodine atom from a thyroid hormone molecule - it deiodinates it.

On this forum we probably understand, but if you wish to look it up anywhere, it might help to get it right. If you are discussing with a doctor, and get it wrong, you are providing an excuse for them to dismiss what you say.

(More strictly, two single-nucleotide polymorphisms (SNPs) on the DIO2 gene, rs225014 and rs225015.)

academic.oup.com/jcem/artic...

The Wiki article provides a basic introduction as to what a single-nucleotide polymorphism (SNP) is and why it can be important:

en.wikipedia.org/wiki/Singl...

[FancyPants54 in reply to helvella]

Ha! I've never noticed that. I still looked at what you had written and couldn't see it for a moment.

[SlowDragon Administrator]

If you haven't seen this post, you might find it interesting

healthunlocked.com/thyroidu...