Tpo carbizamole and talking white cell count. - Thyroid UK

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Tpo carbizamole and talking white cell count.

28 Replies

Hi posted yesterday about a rash on back. Had blood test Wednesday resujts TSH 0.01.

White blood cell count 4.12 from 6.1 two weeks ago. Normal lab range 3.4 to 8.4

Tpo antibodies 54 lab range 0 to 6

I have been taking carbizamole for two months 30 mg.

Diagnosed with graves at the same time.

Any thought?

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28 Replies
Rmichelle profile image
Rmichelle

Tpo are hashis antibodies, tsi is graves, I have hashis >900, you have mild hashi at 54,.

I take it you are still on carbimazole as you are within range for white blood cell count, mine has gone down to whilst on carbi but within the range.

You still need a full thyroid panel tsh alone is nothing, other forum users will agree. A suppressed tsh is normal, mine was suppressed for months, what does matter is your ft3 and ft4? You need to insist this are done gig👍 I will let others comment. 😁😀

in reply to Rmichelle

Both ft3 and ft4 were both well raisdd

greygoose profile image
greygoose

Did they test your Grave's antibodies before giving a diagnosis? You can have both Grave's and Hashi's, but if you have Hashi's, you're on the wrong treatment.

Rmichelle profile image
Rmichelle in reply to greygoose

Again another Endo making a right dogs dinner of something, you have graves because they say so!!

Rmichelle profile image
Rmichelle in reply to greygoose

Looking at his bloods greygoose he has mild hashis tpo 54.

in reply to Rmichelle

With low TSH and high T3 and T4 I thought that the endo was correct in graves the loss of weight and sweating bring more symptoms

greygoose profile image
greygoose in reply to

Yes, but you can have low TSH and high Frees in Hashi's, too, engendering loss of weight and sweating, etc. That's why the correct antibodies should be tested to distinguish between the two. :)

greygoose profile image
greygoose in reply to Rmichelle

Just because his antibodies are low, doesn't mean his Hashi's is 'mild'. Antibodies fluctuate. But, in any case, the antibodies are not the disease and the level of the antibodies does not indicate the severity of the disease. :)

in reply to greygoose

I'm seeing doctor at 340 what would be the best test I need to differentiate between the diseses

greygoose profile image
greygoose in reply to

For Grave's you need TRAB or TSI tested. That's the only way to know for sure.

in reply to greygoose

I'm wondering whether what to discuss about the carbizamole I'm on 30 mg a day and have a rash on one side of my back. My symptoms haven't improved and maybe worsened since I have been on these tablets. Any thoughts or ideas guys

greygoose profile image
greygoose in reply to

What were your last FT4 and FT3? Do you have your results from diagnosis?

Rmichelle profile image
Rmichelle in reply to greygoose

Thankyou for correctiong me, perhaps I should have said it like slowdragon"mildy raised tpo" 😀

greygoose profile image
greygoose in reply to Rmichelle

Mildly raised TPO antibodies would be more correct. :)

in reply to greygoose

My TSH was 0.01 ft4 was 25.1 ft3 was 15.1

greygoose profile image
greygoose in reply to

They're not very high for Grave's. Those are more like Hashi's 'hyper' swing results.

in reply to greygoose

Just been to doctors she's not too impressed by my rash need to watch it and if it worsens over weekend seek attention. She has arapranged more antibody tests including the graves one for next Wednesday we shall see

Valarian profile image
Valarian in reply to

was this a recent test, or from before you started the Carbimazole ? Also, labs use different reference ranges, so if you quote a thyroid result, to make sense of them we really need to see those as well (typically in brackets after the result).

Valarian profile image
Valarian in reply to Rmichelle

65% of people with Graves' have elevated TPO (but not so high as for Hashi's) - it isn't specific to Hashi's, rather an indication of autoimmune thyroid disease, which applies to both Graves' and Hashi's

Rmichelle profile image
Rmichelle in reply to Valarian

Aha right thanks valarin, Endo says I have graves, but I also have hashis which was tpo result of >900 range ended at 50, 2 scans indicating hashi also but like many others here Endo refuses tsi has he reckons everyone who is hyper has graves, all 3 of my endos refused tsi and said the same. Not good is it.xx😁😁

Valarian profile image
Valarian in reply to Rmichelle

I've never seen TPO ranges published for Graves' and Hashis, which suggests there may be more to it than simple numbers. However, people here with Hashi's often quote TPO >1000 (and yours is pretty close to this). while people with Graves' seem more likely to have levels of a couple of hundred. It seems to be perfectly possible to have Graves' and Hashi's simultaneously but obviously you can't be both hyper and hypo at the same time. Also, your thyroid levels were elavated for quite a long time, weren't they ?

Did you not have TRAb tested, if not TSI ?

It really does seeem to be a bit of a 'postcode lottery' with getting a good thyroid endo.

Rmichelle profile image
Rmichelle in reply to Valarian

Yes they were high for a while V, I keep trying for this test still.....they think it's pointless, they would not entertain either test😠. I see Endo next Tuesday so we will see, he will say, "pointless exercise move on" so rude he is,xx

Valarian profile image
Valarian in reply to Rmichelle

I guess you’ve run out of endos to sack, Rmichelle!

I had TRAb done at my first endo appointment, and am scheduled to have it done again at my next. Thyroid levels currently mid-range, although they’ve need the length of time I will be on carbi by another three months, and think the treatment has taken too long, and the level of carbi required has been too high, for me to stand a god chance of making remission

Rmichelle profile image
Rmichelle in reply to Valarian

Lol I maybe on no4 soon eh!!,😁😁 yes I have around another 3 months too, I feel carbi is making my symptoms worse, I just get the feeling that maybe I do not need it, having bloods done this week in hope my frees have not still remained at the low level, I hope you have a good chance of remission V, is the next step for you surgery? This has been mentioned to me already.xx

SlowDragon profile image
SlowDragonAdministrator

You can have mildly raised TPO or TG antibodies with Graves, not just Hashimoto's

Definitely need TSI or TRab antibodies tested for Graves

thyroiduk.org.uk/tuk/about_...

in reply to SlowDragon

I have further blood tests tomorrow should be interesting my white cells have fallen from over 6 to 4.12 in two weeks . Lab range 3.4 to 8.4 should be interesting to see results of tomorrow's test

SlowDragon profile image
SlowDragonAdministrator in reply to

Make sure to get printed copies of all your blood test results and ranges. You are legally entitled to these, they can not refuse or charge for them

Come back with new post once you have results

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helvellaAdministratorThyroid UK

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