We also have a paper in the European Journal of Clinical Investigation accepted today as well. It will be available soon. It shows that, as the thyroid function declines, the whole system of body and thyroid whips up T4-T3 conversion to try to maintain FT3 in the body as close to normal as possible in the face of a reducing T4 supply. When thyroid function is getting very close to zero, the frenzy suddenly collapses and a new situation arises where the relation between T3 and T4 becomes very unstable. This leads to quite different needs for control of treatment for those who have some thyroid function left as opposed to those who have none.