This paper will soon appear in Journal of Thyroid Research, It's extremely important as it asks the question as to why basic physiological discoveries about how the thyroid and body interact are not mirrored equivalently by clinical trial results, that do not consistently support combo therapy over mono therapy with T4. Put simply, ALL randomized clinical trials attempting to answer this question are faultily based, and by their basic error in statistical analysis and inadequate power of numbers of patients, cannot address the questions they are asking. We go into great detail as to how this should be so and suggest remedies for better trial design in the future. The irony is that NICE are at present drawing up guidelines based on the very completely flawed "evidence" from trials. Obviously it follows their conclusions are fatally flawed and no weight can be given to the outcome if it is based on such work. It should not take too long for this paper in J Thyroid Research (an open journal) to be published and when this happens, it should be addressed to the NICE deliberators to give them pause for thought. The title is:
"Lessons from Randomised Clinical Trials for Triiodothyronine Treatment of Hypothyroidism: Have They Achieved Their Objectives?"
It will quite a blow for the thyroid establishment to find they have wasted their time and come to wrong conclusions as a result.