Response to Dr Anthony Toft's article in Journa... - Thyroid UK

Thyroid UK

140,917 members166,037 posts

Response to Dr Anthony Toft's article in Journal of RCP

lynmynott profile image
lynmynottPartnerThyroid UK
6 Replies

A response to Dr Anthony Toft's article, "‘Thyroid hormone replacement – a counterblast to guidelines" has been published today in the Letters to the Editor section of the Journal for the Royal College of Physicians.

The authors refute Dr Toft's comments that their 2010 paper was flawed and also state, "Evidence-based guidelines describe a

foundation of knowledge, but should not be the ceiling of clinical practice."

They also state, " Far from restricting the development of evidence-based guidelines, we need to be educated to use them constructively and to ensure they are not misinterpreted or misused by people who do not have a patient-focused agenda."

Thyroid UK completely agrees with the authors and looks forward to any training that may be set up for doctors to understand that guidelines are not meant to be used as a one size fits all solution to diagnosis and treatment.

rcpe.ac.uk/sites/default/fi...

Written by
lynmynott profile image
lynmynott
Partner
To view profiles and participate in discussions please or .
Read more about...
6 Replies
diogenes profile image
diogenesRemembering

The problem of interpreting the results in the papers is as usual: shoehorning, diagnosing by category instead of individually, mixing up statistical likelihood of a patient group with actual likelihood for the individual. One simply cannot use evidence-based medicine in this generalised way - the statistical analysis is wrongly based and by mixing up patients, simply causes undue alarm to the individual say with a TSH of <0.01 who may NOT be prone to bone fractures, as opposed to another who may. TSH of <0.01 for one person may represent overdosing, but adequate dosing for another.

jgelliss profile image
jgelliss in reply todiogenes

Diogenes and lynmynott

THANK YOU !!! For Validating Patients . Patients know the Very Best What Feels Right for them . Don't second guess Patients Please .

Are you going to believe some paper or Patients ???

jimh111 profile image
jimh111

In full agreement with Lyn and diogenes.

There is a statistical association between very low TSH levels and cardiovascular disease and fractures academic.oup.com/jcem/artic... . However, this is what I would call a 'random' association - in general these patients have a very low TSH by chance, patients rarely get a careful clinicial assessment when thyroid hormone is titrated. These patients have been prescribed hormone on the basis of diagnosis and treatment by blood test rather than assessing clinical need by examination of the patient's signs and symptoms.

It is interesting to note that a later study by Leese press.endocrine.org/doi/10.... found no increased risk for patients receiving liothyronine. Although liothyronine is inherently more hazardous (it bypasses deiodinase protective mechanisms) it would seem the extra care taken by doctors willing to prescribe liothyronine more than makes up for any potential risk.

The surveys tell you what happens if TSH is suppressed at 'random', either by need (to prevent cancer returning) or by accident. When TSH is suppressed on careful clinical grounds there appears to be no additional risk with the benefit of making the patient well and avoiding risks associated with clinical hypothyroidism.

helvella profile image
helvellaAdministrator

See:

healthunlocked.com/thyroidu...

loueldhen profile image
loueldhen

From a 'lay' perspective - I was alarmed to think that two of the 'good guys' were arguing! But having looked back - it all looks understandable. Phew. I was worried for a moment.

lynmynott profile image
lynmynottPartnerThyroid UK

I was at first too! :-)

Not what you're looking for?

You may also like...

Email to Dr Anthony Toft

Hi All Earlier I wrote an email to Dr Anthony Toft regarding the impending ban on t3 prescribing...
Kitti1 profile image

In response to: 'Thyroid hormone replacement - a counterblast to guidelines'

Just saw an alert for a new item - in response to Toft's Thyroid hormone replacement - a...
helvella profile image
Administrator

Dr Anthony Toft speaks out in “Thyroid Hormone Replacement - a counterblast to guidelines”

Dr Anthony Toft speaks out in a counterblast article in the Royal College of Physicians of...
Pamela0106 profile image

'Reference intervals in the diagnosis of thyroid dysfunction: treating patients not numbers' - Lancet journal article

Just received the latest Lancet 'Diabetes & Endocrinology' journal info ( Volume 7, ISSUE 6,...
AmandaK profile image

Power of Dr Toft article

Just wanted to share my latest Thyroid experience at the doctors. In a nutshell I wanted the doctor...
Dotty1340 profile image