Hemiplegic Migraine

[Paula101]

I've had these decades and wondered if anyone else has them. If so what treatment do you take that works?

[Hashihouseman]

if you're on Levothyroxin it may be a histamine toxicity side effect. You could try simple hay fever relief antihistamines to see if they have any ebkct. The headaches could also be persistently active TSH pulsing ...... do they get better with T3?

[George1962]

Hi, my adult son has recently started taking beta blockers which have had a dramatic effect. they havnt completely gone but are far less often and the pain is manageable. He still gets a slightly droopy face etc but feels so much better.

[Paula101 in reply to George1962]

It's good of you to get back to me thank you. Yes, I still get a droopy lip & face but not slurred speech anymore, that's the only symptom I don't get. I remember beta blockers knocked me out!

There may be a solution in what I did last night. Took usual nightly dose of Magnesium Glycinate & within 10 mins my migraine had gone. Was not expecting that but was a wonderful surprise. So will be monitoring things on that score.

And thank you again 🙂

[George1962 in reply to Paula101]

Ah, might suggest he tries that. 😄

[Paula101 in reply to George1962]

Fingers crossed it'll help 🙂

[Paula101]

Thanks for replying. Must admit I'm not on Levo or Lio. I take Nutri Advanced products.

You mention the TSH pulsing, thanks for that I'll google it & read up, not heard of that.

Much appreciated 🙂

[helvella Administrator]

Afraid I have no useful information for you.

I did fall over two things, though, which might be of some slight interest:

Mol Biosyst. 2016 Nov 15;12(12):3674-3682.

Metabolomic changes in CSF of migraine patients measured with 1H-NMR spectroscopy.

Zielman R1, Postma R2, Verhoeven A2, Bakels F1, van Oosterhout WP1, Meissner A2, van den Maagdenberg AM3, Terwindt GM1, Mayboroda OA2, Ferrari MD1.

Author information

1 Department of Neurology, Leiden University Medical Center, P.O. 9600, 2300 WB, Leiden, The Netherlands. [e-mail].

2 Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.

3 Department of Neurology, Leiden University Medical Center, P.O. 9600, 2300 WB, Leiden, The Netherlands. [e-mail] and Department of Human genetics, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

BACKGROUND:

Migraine is a common episodic brain disorder. Treatment options and diagnosis are hampered by an incomplete understanding of disease pathophysiology and the lack of objective diagnostic markers. The aim of this study was to identify biochemical differences characteristic for different subtypes of migraine in cerebrospinal fluid (CSF) of migraine patients using an exploratory 1H-NMR-based metabolomics approach.

METHODS:

CSF was obtained, in between migraine attacks, via lumbar puncture from patients with hemiplegic migraine, migraine with aura, migraine without aura, and healthy controls. Metabolite concentrations were measured by quantitative 1H-NMR spectroscopy. Multivariate data analysis was used to find the optimal set of predictors, generalized linear models (GLM) were used to ascertain the differential significance of individual metabolites.

RESULTS:

In CSF samples from 18 patients with hemiplegic migraine, 38 with migraine with aura, 27 migraine without aura, and 43 healthy controls, nineteen metabolites were identified and quantified. Hemiplegic migraine patients could be discriminated from healthy controls using supervised multivariate modelling with 2-hydroxybutyrate and 2-hydroxyisovalerate as the most discriminant metabolites. Univariate GLM analysis showed 2-hydroxybutyrate to be lower in hemiplegic migraine compared with healthy controls; no significant differences were observed for other metabolites. It was not possible to discriminate migraine with and without aura from healthy controls based on their metabolic profile.

CONCLUSIONS:

Using an exploratory 1H-NMR metabolomics analysis we identified metabolites that were able to discriminate hemiplegic migraine patients from healthy controls. The lower levels of 2-hydroxybutyrate found in patients with hemiplegic migraine could indicate a dysregulation of the brain's energy metabolism. An experimental confirmation in vitro or in animal models will be required to confirm or discard this hypothesis. Migraine with and migraine without aura patients did not reveal a metabolic profile different from healthy controls.

PMID: 27734045

DOI: 10.1039/c6mb00424e

ncbi.nlm.nih.gov/pubmed/?te...

Hemiplegic migraine and stroke in Mary Shelley

Philippe Charlier, Otto Appenzeller, Saudamini Deo, Antonio Perciaccante, Raffaella Bianucci

Published: April 2018

DOI: doi.org/10.1016/S1474-4422(...

Mary Wollstonecraft Godwin Shelley (1797–1851) was the author of Frankenstein; or, the Modern Prometheus. In 1839, she had recurrent, severe headaches whose severity, location, and duration were variable.1 These headaches were associated with dizziness; pain in the legs, right hand, and right eye; and episodes of transient partial paralysis of the right leg and hand, with tremors, convulsive seizures, and severe pain on the top of the head.2 She was diagnosed with psychosomatic illness in 1842, “functional derangement in the nerves or brain” in 1845, and back pain and “neuralgia of the heart” in 1846.

thelancet.com/pdfs/journals...

However that is all you can see without paying a fortune.

[helvella Administrator in reply to helvella]

You might care to take up writing novels, if you don't already.

[Paula101 in reply to helvella]

Helvella, thanks so much 👍🏻😀

I can't wait to sink my teeth into the info. I really do appreciate you taking the time. As it happens I've been photographing (use my phone for the forum) particular posts so I can transfer all the info into a HUGE book!

My brain fog is much better than it used to be but I've always found writing things down helps info to stick in my memory. Thanks again.

[Paula101 in reply to helvella]

Dysregulation of the brain's energy metabolism sounds genuinely fascinating. I'll be delving deeper. If Mary Shelley was around we could have talked endlessly comparing notes. Thank you again. That's why I love this forum so much, I'm constantly learning all the time. I miss my school days!

[helvella Administrator in reply to Paula101]

Well energy bit did at least hint at a possible thyroid hormone association.

[Paula101 in reply to helvella]

Yes, I agree 🙂