ANA and DRVVT: My dermatologist ordered a series... - Thyroid UK

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ANA and DRVVT

phirestar profile image
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My dermatologist ordered a series of tests because I don’t seem to be doing what most do after using efudex cream on a couple of spots on my nose. Does anyone know what this means?

Negative ANA

PTT-LA screen negative

36 seconds <=40 seconds

DRVVT screen positive

58 seconds <=45 seconds

Thx

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phirestar profile image
phirestar
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milkwoman profile image
milkwoman

I had to look up DRVVT Screen and found that it is a test for lupus anticoagulants.

“Lupus anticoagulants are antibodies against substances in the lining of cells. These substances prevent blood clotting in a test tube. They are called phospholipids. People with antibodies to phospholipids (aPL) may have a very high risk of forming blood clots.“

Contrary to the name ‘lupus anticoagulant”, this ISN’T a test for lupus (SLE). It would seem that you have tested slightly positive for APS (Auto Phospholipid Syndrome or Hughes Syndrome). However, Have you had any blood clotting issues? You may require further testing to see if treatment is required.

Great info here: labtestsonline.org/tests/lu...

You may want to post this on the APS forum as folks there may have more knowledge/insight.

phirestar profile image
phirestar in reply tomilkwoman

I’m 68 and no blood clot problems yet. I was put on mylan levo at 65 and reacted. My files now say allergic to mylan, synthroid and omnipaque 300. With the omnipaque I turned blue in extremities, shakey and very cold. All my reactions were firsts. My first ANA was positive resulting in a cascade. SSA was 1.0 (<=.9). I did 23/me bc I’m asymptomatic for hypo/hashi. I know I have some odd/rare genes. I’m Caucasian but carry genes for sickle cell trait! - a blood disorder. Since this ANA was negative there was no cascade. The PPT la was negative the other positive. Do you know what this might mean? I’ll look up Hugh’s syndrome and see what it says. Thanks for the reply. Thx

milkwoman profile image
milkwoman in reply tophirestar

Hmmm, so you’ve had a positive ANA and also positive SSA (specifically which SSA?) Coujd be pointing to Sjogrens. .

In any event, it does sound like you have something rheumatological going on. Perhaps it is time to see a rheumatologist and get a full blood work up and urinalysis.

phirestar profile image
phirestar in reply tomilkwoman

The positive ANA was 8 months into all my reactions to mylan (8/15). My first reaction was in my eyes. Once on Tirosint, all the reactions stopped and I haven’t returned. My recent eye dr visit said eyes are great and the minor dry eye that I have is probably related to age and wearing contacts since I was 10. I don’t seem to have any other symptoms for sjogrens. I’ve done some further reading and it looks like the DRVVT test is more sensitive. Due to age (68), and no prior history of clotting issues it’s interesting. One of my reactions to mylan was I looked like someone had taken a baseball bat to my thighs - lots of widespread bruising. I was put on low dose aspirin and got different bruising. Stopped the aspirin and do fish oil. The negative ANA was 3/18 along with the DRVVT. My medical record number got mixed up with someone else (male w cirrhosis) from a doc that I don’t see so a full liver panel was done. This surfaced at the cardiologist office and I couldn’t figure out how I had cirrhosis. The lab work helped track this down and that doc is sending me my liver panel! I’m waiting to hear from Dermotologist now. It’s almost like my body is waiting to see what other autoimmune disease it wishes to manefest ! I did 23/me bc I had no idea what labs to chase bc I seem to be asymptotic. That has provided more info than anything else so far and has helped to sort out my weird reactions. Im looking at genetics again and I’m hetero on snp for APS.

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