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Thyroid UK
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Help need pulse article

Can anyone help me. I have emailed Dionne on the thyroid uk team and asked for this article and have had no response. I am due to see my endo tomorrow evening and am desperate to take along any information that would help, could anyone send me this article. Could I find it on the internet? Does anyone in the admin team know how I could get a copy ASAP

Thanks in advance

5 Replies

Hattie19, I can send it you if you PM me your email

1 like

Thanks megarub, I have just PM you. Your rapid response is much appreciated



The main Thyroid Office have been closed over Christmas/New Year so there will be a backlog awaiting when they return to the office.

If you click on megarub's name you can send her your email and she'll send you a copy.

Also print-out the following article and send to both your Endocrinologist and your GP as it is by one of the eminent UK Endocrinologists and even he has had second thoughts about some needing T3 added to T4.



Thanks Shaws, I will print this other article out and leave it with him to ponder. I will read it and see if I can highlight any specific bits that will enable him to skim over it whilst I’m in there.

Thank you as always for being there, it is so much appreciated


1 like

There is a couple of excerpts which you could highlight:. The following for instance:-

Excerpt 1:

In the early 1990s I was involved in the initiation of

guidelines in medicine, in the UK at least, when President

of the Royal College of Physicians of Edinburgh. It was

one of many errors of judgement in my long professional

career. Their development was encouraged by government,

during one of its recurrent financial difficulties, in order to

deliver a higher level of healthcare throughout the country

without having to replicate major teaching hospital services

in smaller and often geographically remote hospitals. The

unforeseen consequence is that guidelines have assumed a

clinical and legal importance far beyond that which was ever

intended by their protagonists. Although their consensus

recommendations are rightly qualified by the acknowledged

variability of the quality of evidence, it is the key statements

which are seized upon by the non-expert, and not the

reservations. It is as if guidelines, like the tablets given to

Moses on Mount Sinai, have been carved in stone for a new

generation of doctors that seems duty-bound to follow each

edict slavishly. The impression is that young physicians have

ceased to think, ceased to challenge received wisdom and

ceased to recognise that patients come to the consultation

as individuals, expecting to benefit from the opinion of an

open-minded and experienced professional

Excerpt 2:

The facts of the matter are that the current guidelines for

LT4 replacement therapy in primary hypothyroidism are not

fit for purpose and the continued reluctance to approve

additional treatment with liothyronine denies the patient the

precision medicine which we are encouraged to adopt,

10 and which many patients crave. In the future, D2 genotyping may

play a role in identifying those patients likely to benefit from

treatment with both thyroid hormones.


In the meantime, I am so concerned about the state of advice on the

management of primary hypothyroidism that I am increasingly

reluctant to suggest ablative therapy with iodine-131 or

surgery in patients with Graves’ disease, irrespective of age

or number of recurrences of hyperthyroidism. Treatment with

a thionamide, in which the hypothalamic-pituitary-thyroid

axis remains intact, making interpretation of thyroid status

simpler, is currently a more attractive proposition. It is not

that I am unprepared to disregard guidelines by prescribing

‘a little too much’ LT4 or combined thyroid hormone therapy,

but I know that an increasing proportion of primary care

physicians, advised by guidelines, will not accept my

advice. Experience of managing more patients with thyroid

disease than most over a period of some 40 years is being

trumped by inflexible guidelines; truly a remarkable state

of affairs. Others hide behind guidelines to avoid the cost

of prescribing liothyronine, which in the UK is exorbitantly

priced by the sole supplier at some £250 for two month’s

supply of 10 μg daily, when well-travelled patients can obtain

supplies for a few euros in Italy and Greece and beyond.

(ps have highlighted in bold)


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