D102 genetic test back does anyone know what they mean?

[Pascha1]

I got my Dl02 gene test results today but have to wait few days for consultation for them to explain it all? Has anyone else had same results and know what they all mean please? Dl02 Genetic polymorthhisms implicated in various pathways Result Deiodinase, lodothyronine type ll. Dl02 (T92A) rs225014 Heterozygous variant genotype TA ?

[SlowDragon Administrator]

If you have inherited from one parent it's heterozygous and you have impairment or difficulty converting T4 to T3

If you inherited from both parents its homozygous. This means even more difficulty converting

You should get it all explained at the consultation

Are you sure it says Holerazygous?

[Pascha1 in reply to SlowDragon]

The writing isn't that clear maybe the way you wrote it ? My eye sight isn't that brilliant at night sorrr it looks similar to both

[Pascha1 in reply to Pascha1]

Ho?ozyguos

[ffranny in reply to Pascha1]

possibly homozygous? you need to clarify with them I guess

[ffranny in reply to Pascha1]

Hi just slightly off tangent, my night vision became very very poor over a number of years. I didnt think to associate with anything but when I changed from Levothyroxine to Natural dessicated thyroid, one remarkable thing out of many was that my night vision came back , not perfectly but far better than before. Of course no one in the health professions accepts my eye propblems are linked tothyroxine or underactive thyroid...

[Baggiebod in reply to ffranny]

Hey that's interesting! My night vision has deteriorated to virtually night blindness and when I think about it, it definitely seems to correspond to when I began taking Levothyroxine! Thanks for the information!

[ffranny in reply to Baggiebod]

Hi yes, someone told me that thyroxine, T4 prevents uptake of vitamin A. I dont know for sure, just that what happened to me seems to link thyroxine to night sight issues.

[Pascha1 in reply to ffranny]

yes I also suffer with night vision , and I cant stand bright lights i cant even go to Tescos as lights do my head in

[Baggiebod in reply to Pascha1]

I'm ok with bright lights, but cannot see properly at all in dim light or twilight. Unable to drive after dark now as I'm not really safe!

[mourneadventurer in reply to Pascha1]

Check out the ability to cope with bright lights might be linked with adrenal issues. Dr Alan Christensen does a health questionnaire on this.

[TSH110 in reply to ffranny]

ffranny Me too it is better on NDT but still rubbish I never twigged it was due to the thyroid disorder till I read something that mentioned it. It must be an early symptom because it was poor for many years before diagnosis.

[Pascha1 in reply to SlowDragon]

It is Heterozygous SlowDragon My eye sight must be bad so is inherited by 1 parent and i do believe i do have problems converting it as have felt ill since i became hypo , i phone my Endos secretary today with the results and she seemed very pleased i had them and giving them to the Endo later, so will be interesting to hear what he puts in GP letter for prescribing me the T3 for next month , so sounds like i will keep to the 20mgs T3 with 100mg of levothyroxine , or will i be better on T3 ?

[SlowDragon Administrator in reply to Pascha1]

Well I have heterozygous too

I am now on 125 T4 and 20 T3

I think DIO2 result has helped to keep my prescription....so far

It’s been astonishing improvement.

Took 22 years of hell on T4 before need for T3 was finally recognised

[TSH110]

If you look at this link and scroll down you will come to the one you have the result for. Odd thing is TA is not given as a result

geneticlifehacks.com/thyroi...

So not sure what to make of it. I have a reduced conversion combination that is listed.

rs225014

CC: decreased DIO2 enzyme (T4 to T3 conversion) [ref]

CT: decreased T4 to T3 conversion

TT: normal DIO2 enzyme

Perhaps you are in the clear with it or 23&me gives the info in a different way to other tests. Maybe others can shed more light on the result for you.

[snrise2801]

Because this faulty gene D102

causes a deficiency of T3 within the cells, the usual thyroid hormone function tests will not show up a problem. This means that your TSH, FT4 and FT3 blood tests will look normal.

[Pascha1 in reply to snrise2801]

so do they still give you t4 if the bloods are not reading whats happening in your body ?

[humanbean]

The faulty gene is DIO2 not D102 i.e. it is three letters and a number.

.

Poor night vision could be due to low vitamin A. If you were to search for Vitamin A supplements, most of the ones that came up would be made from carotenoids such as beta-carotene. Unfortunately, beta-carotene isn't actually vitamin A, it is a pro-vitamin i.e. it is one of the raw materials needed for the body to create vitamin A itself.

And guess what? Many hypothyroid people can't do that conversion very well, so we end up with loads of carotenoids in the body and not enough proper vitamin A. If you have this issue it might show up in your hands and feet - the palms of your hands and/or the soles of your feet might be very orange compared to those of healthy people.

The way to help yourself is to buy true vitamin A and supplement. Vitamin A is fat soluble so take it with a fatty meal.

empoweredsustenance.com/tru...

selfhacked.com/blog/importa...

[mourneadventurer]

You need to check the spelling of hetero or homo zygous.

The former meaning a genetic polymorphism from one parent and the latter from both. Either way you will have issues converting from T4 to intracellular T3. Potentially leaving you clinically hypothyroid at cell level.

Suzy Cohen - Pharmacist wrote a brilliant article on this yesterday which you might find helpful suzycohen.com/articles/reve...

Check that you have all of the minerals and water and fat soluble vitamins in place for that conversion. Thyroid Uk is helpful.

Different forms of stress including toxins block the conversion as well. So you’ll need to start eliminating them by focusing on diet, lifestyle, environment factors.

The poor night vision is linked to oil based vitamin A mention this to your genetic counsellor who might suggest a functional nutrition approach.

I’ve got down that route as dosing needs to be tested and not guessed.

[Hidden in reply to mourneadventurer]

Thanks for the Susie Cohen article. The more I read the more I learn it's very interesting about RT3 I didn't really understand before.

[Pascha1 in reply to mourneadventurer]

it was hetero sorry it wasn't that clear but got the consultation today and its i have one parent pass the gene to me

[Ari3 in reply to Pascha1]

I have the same from one parent does it mean that NDT will work on me ?

[Pascha1 in reply to Ari3]

It means you will do better with T3 added, I feel much better with T3 added, I haven’t rued NDT but that does have T3 in it .

[Ari3 in reply to Pascha1]

What are ur doses u r on at the min? Have u got more t3 rather than ndt?

[mourneadventurer]

My pleasure Bunnyjean,

Basically our failsafe method for hibernation is Reverse T3 and we may not be aware of the underlying stealth infections etc that are blocking the conversion. Those things as well as a DIO2 genetic polymorphism will push us towards covert hypothyroidism and subsequent ill health cascade.