I have been for weeks trying to find more information on the relationship between swelling, specifically swelling attributed to elevated CREATINE KINASE (not to be mistaken for creatinine), and HypoT. My swelling is agonizing, pitting, hyper pigmented, specific to my right calf and foot, upper thighs, lower abdomen and has a hardened tissue feel. My first hearing of the relation was in reading and listening to a Dr. R.K.B. (I'm not sure if doc names are permitted on this forum, hence the initials)- an expert in Type I diabetes, who also treats a majority of his patients for hypothyroid as well, as he believes the two are corralative. In his practice, and personal experience, as he has both Type I and HypoT, this type of particular type of swelling has a certain hard feel and sometimes, reddened on all complexion hughes). It has a cellulite appearance and is difficult to pull up skin in the effected area. Often the tissue over the knee hangs. This swelling is in many cases an initial manifestation of HypoThyroid, but is OFTEN missed or disregarded when it doesn't meet the symptomatic characteristics of swelling typically associated with Graves. It is also misdiagnosed as polymyositis or other primary muscular disorders.
This swelling is seen in hypo, hyper, AND Hashis, though the physiological relation of elevated CK and hypoT is not fully studied. There has, in some case studies, been reported correlation between low FT3 and elevated CK in diabetic and non-diabetic patients. Yet, again, the pathophysiology is yet studied or understood. If you are further interested in this specific HypoT symptom, a good starting reference is as follows:
Thank you for your time. If you have any further information, including successful treatment of this type of swelling (high Creatine Kinase with HypoT suspicion), please feel free to message me.