Have been on Thyroxin for around 30 years. Suffered from varying degrees of depression since my late teens. Have a stressful full time job and all the normal challenges everyone has to deal with. However my Dr's have never explained the symptoms of an under active thyroid and it's only now, at 50, feeling so tired, very low and struggling to keep my head above water I want to understand if any of it has something to do with my thyroid. Been on high doses of anti-depressants for the last 15 years and my GP gas always insisted I must remain on them and now telling me my symptoms are pre-menopause. If that's the case I have been pre-menapausal for 20 years!!!!