I'm sharing some of this bc others might find my story helpful. After spending a year reacting to mylan levo and synthroid I was given tirosint. Thyroid meds were the only thing I was taking. All reactions were T,B and mast cell activated and all were firsts at 65! For the last year (tirosint) all the reactions have stopped. Bc I really didn't have symptoms to chase, I opted to do 23/me as I thought this would provide more info and be more cost effective. I was not disappointed! I have multiple chemical sensitivity (maybe why I reacted to mylan and synthroid) and a number of other interesting uncommon mutations (less than 25%). My hypo/hashi genes are also interesting as I'm +/- on the only hypo gene I've found so far and the hashi genes came back inconclusive or no call based on what I've found so far. I found certain uploads valuable in that I was taking the wrong forms of some supplements so I'm swapping that out. All the above served to confirm my outlier status. Docs were of no help through this. I found sites like this and others to be more helpful than the medical Community-sorry to say. So thank you for your help and a great site.