I would really appreciate some advice from those on T3 only. My dose has slowly been increased to 40 mcg and after each increase I feel an improvement then after a few days things seem to revert back to being not so good. I struggle at work and find I can't join in with normal activities at home. I don't seem able to cope with any slight stress at the moment, whether at work or even just having family to stay and wondered if it could have something to do with the adrenals/adrenaline/cortisol levels due to perhaps having been under medicated for some time. I was due to go away this weekend with friends but have declined as I don't think I could cope with the buzz of it all! Having been on T4 and felt dreadful for a long time and battled to get T3 prescribed, I am desperate to find a solution. Can anyone help?