One time I took the pill without water, after an hour I noticed it is still in my throat and I had to drink water to let it go through to my stomach ... that day I felt extreme fatigue .. I'm sure it is because of the medicine was unstable by the time it was my gut for absorption. I know this because I got theses symptoms when my medication once exposed to high temp.
So, what about Diluting Levothyroxine in Water? Is it a good idea?
Ali1101,
Levothyroxine is designed to be swallowed and washed down with water. If you don't have a problem swallowing tablets without water why do you need to dilute Levothyroxine in water?
No problems but I thought that the longer it takes the pill to be absorbed the worse the quality will be. Not sure I'm just assuming this!
Levothyroxine swells in water. This is why it should always be swallowed properly with sufficient water to wash it into the stomach completely as soon as it goes in the mouth. Getting it stuck in the throat is a known issue for people who don't drink it with enough water.
I can't see why you would want to dissolve it in water, and I don't think it would be a good idea. Just take it with the water instead. If you dissolved it you could end up losing some of it stuck to the side of the glass or left in the drops of water that don't come out in the bottom of the glass.
The ideal way to take levothyroxine is with one full glass of water otherwise there is danger of it swelling on your throat.
I'm terrible at swallowing pills so I use a pill cutter. The protective layer in my NDT was relatively thick so cutting it can only speed up absorbition - creating a greater surface area and all that.
I've had pill stick in my throats and burn me. It was horrific - think it was some old anti anxiety meds.
Yes, levothyroxine CAN be dissolved in water. I too, have felt the pill stick in my throat --even after drinking several glasses of water. Levothyroxine is an especially powdery pill, which expands with contact of water... It can expand while IN your throat, which is uncomfortable.
As a nurse, we do crush and dissolve Levothyroxine in a syringe of water to give to our tubefed patients, or others who can not tolerate swallowing pills.
Best way is this: Take a needle-free, 10 mL syringe intended for tube fed patients, (an "enteral" syringe, NOT a luer-lock syringe. No needle is involved. Ask your pharmacist how to obtain, often, the pharmacist can hand you a few for free.)
Remove the plunger part of the syringe, set aside. Now place that little cap back on the tiny tip of barrel part of syringe. Next I set the syringe open-end upwards inside an empty pill bottle to hold it from falling over.
Now, Fill syringe about half way full by pouring in a few mL of water. Now drop in entire pill into that water, do this the night before, and by morning, it will be dissolved inside your syringe.
In the morning, now place the plunger part of syringe inside the syringe, remove the tiny cap off the small end of syringe,
and simply push the syringe fluid into your mouth. It will taste badly, quickly swallow glass of water. To ensure no granule of your Levothyroxine is left behind in syringe, draw up a few more mL of water into the now empty syringe and inject That as well, into your mouth. Again, chase with glasses of water.
This IS a good solution to that problem of feeling that very powdery pill of Levothyroxine sticking to throat and expanding/dissolving in your throat. It also helps with faster absorption.
Levothyroxine is almost insoluble in water.
You can disperse a levothyroxine tablet in water.
Levothyroxine is a bit more soluble in an alkaline environment. Which is partly why most of a swallowed dose gets absorbed in the first part of the gut - where it is alkaline - rather than the stomach.
For many people, including most of those not on tube feeding, simply dispersing a tablet in a small glass of water should suffice. Yes, do add and swallow a second lot of water to make sure nothing is left behind. But the syringe doesn't really help very much if the person can eat and drink fairly normally.
By the way, this post is over three years old. I hope the original poster has got over the problem by now! 
Taking water with thyroxine tablet 
Levothyroxine and eating
Liquid levothyroxine 
Tap and bath water filter
What works for water rention?
