I have upped my Levothyroxine to 100 mcg a day from the prescribed 75 mcg. I take it first thing in the morning on an empty stomach. I am doing this because it feels 'right' for me. I have been tired, sleepy, with joints aching also confused with memory loss. My last blood test was in July last year (16) and showed a good level of TSH and free T4. Replies to my previous post indicate that these levels may have dropped over the year. What confuses some of these issues is that I have ME and a mental health condition; so these feed in to any 'cure' that might exist.