I can't seem to tolerate any meds anymore - Thyroid UK

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I can't seem to tolerate any meds anymore


Hi all,

Just after some advice. I've had a history of struggling with meds since I was diagnosed with hypothyroidism in 2001. I've pretty much tried every brand of T4 and only found success with Evotrox liquid for a short while before it was discontinued. For the last two years I've barely been able to tolerate anything and i'm struggling to function. I feel so much better when I'm not on anything, but that only lasts for a short while before I start feeling hypo again. I should be on 125mcg, but I can't even tolerate 25mcg for one day without getting bloated, sore stomach, irritable and dry, itchy skin to name a few of my symptoms. I've tried purified thyroxine (martindales) and recently tried T3 only but half a 25mcg tablet taken each day for three days has sent me over the edge. The weird thing is I also gain weight when I take meds, and lose it (just a couple of pounds) when I'm off it initially.

I'm getting on a bit and have put having a family on hold as I've been feeling ill for years, but time is running out. I know you need to take more meds in pregnancy but I can't even tolerate the smallest amount anymore.

Any advice or suggestions would be most welcome.

Thanks in advance.


19 Replies


Have you tried other liquid thyroxine?

What do you mean by 12.5mcg T3 'sent you over the edge'?

Evotrox liquid is the only one that worked for me. I've had 3 days of t3 and all the horrible symptoms - lethargy, bloatedness, sudden weight gain, dodgy bowels - have come back

Thanks for listening


Have you ever tried NDT which is combination T4+T3 derived from pig thyroid? You're unlikely to get it prescribed on NHS but can buy it without prescription. I suggest WP which is supposed to be the most hypoallergenic. Send me a private message if you would like a source.

I have tried armour before - many years ago but I'm willing to try anything now. Thank you - will pm you

I totaly sympathise with u . im experienced similar but only been taking eltroxin for many years a low dose.50.

And cannot tolerate a higher dose.

I do take digest enzymes and probiotics. Also aloe. And fibre to keep my metabolism. Up but recently started to but on hard fat around my abdominal area and gone downhill.

To the point of apathy. But am finding out a lot of alternative medicine. And am writing everything down regards testing. .i feel slightly beter on the cannabis oil which is legal in our country.

I hope u find a informed doctor soon to get to the root of your health and also can advice u to google isobel wentz.

7jaie in reply to 7jaie

I also started geting hard painful fat and i also did take cannabis oil .

Im not sure if its my thyroud or mercury or both. The root is the mercury.

I started yoga also i was fit and active last year and got v2 bouts if flue and a virus and now am feeling so il its so so terrible

Just seeing your post and think you may need to consider checking your adrenals.

I am not 'medical'. However, it might be that they are compromised by your lengthy problems with thyroid and not being able to take your meds. However, if you have an underlying adrenal issue this would make it very difficult for you to process you medication properly. It can inhibit the uptake and processes.

This was a problem i had, I never felt better on t4, was fobbed of with a multitude of 'reason's' why this could be - all rubbish. There was a gradual increase in symptoms and increasingly debilitating effects of these symptoms - migraine, fibromyalgia, fatigue etc etc. It turned out this was because my system was not able to convert and use the t4 - so my blood was becoming toxic. I saw Dr P - who sussed this out for me and got me, eventually, onto t3 only. But I did have to work on getting the adrenals up and running better first. If they are compromised you will not get your thyroid sorted and it will have an effect on meds you are trying to take.

Tiredofthis77 in reply to UrsaP

Do they even consider adrenal problems on the NHS? I just can't believe how bad it's got... I should be on 125mcg a day but I can't even tolerate 25mcg for a week. No kidding, I've gained half a stone after taking it for two weeks and my diet hasn't changed.

could you be allergic to a component that the medicine is bound with?.and weight gain may be fluid.

7jaie in reply to UrsaP

What did u take for adrenals i take liquorice root and also adrenal support herbal range. Ashwanga also .

I just took t3 half dose and im going into hyper.

Cannot seem to get the balance

what is a good way to support adrenals

Grey Goose is very knowledgeable on adrenals. Hopefully, she'll pile in, but I have often heard her say that Vit C to tolerance, and Celtic sea salt are very helpful. I have very low adrenal function and am going to try Adrenavive II. (Adrenal cortex only - not the whole gland, which includes adrenaline (?)).

Thank you Steviecat.... Fingers crossed

I take DHEA ? I think that's for adrenals? Mine were completely shot after a saliva test- done by a nutritionist. She was shocked !

Dr Alan Christianson is a naturopathic endocrinologist in the USA and has a very helpful website. He sometimes has courses on how to reset the adrenals. It may be worth a look.


I'm new to site, perhaps my journey can shed light/hope 4 you, Ive been officially-medically termed "hypo" appoximately one year. My Dr. Represents from a excellent facility in USA. WE went thru several medications=didn't blend with me in multiple ways. I asked, after a lot of my own research to try, armour. It isn't covered by my insurance, so I get it compounded. Up until last week, I had bad,bad results in multiple ways. THIS SITE, gave me the info & suggestions. Today, I'm waiting for the mail/show latest results. But, I'm feeling 100% better than the first day I posted. It was a combination of taking supplements, either wrong ones, times, etc. You've found, in my opinion a place where, people understand how u feel, experienced, knowledgeable, abilitiy to supply you with documentation to bring to your Dr., for support in data, all of which was missing in my life. Perhaps yours, regardless I can only hope for you, or anyone else who is struggling/suffering that soon you'll find some relief. Post your blood info, your personal symptoms, ask for help, see what happens. I did, and received alot of replies from so many people knowledgeable, who could relate to how i felt. I hope you, find some direction to feeling better, living a better life, as we're supposed to. Hang in there!🌺

Have you done a saliva cortisol test and that was one of many of my problems for weight gain

Was wondering how you're doing with the medication intolerances. As I just joined this website, I've had hypertension for a few years and a goiter (thyroid) for over 20 years. In the last two years, due to the doctors trying many medications for my blood pressure, I can no longer take anything as I've sensitive or allergic to them all and now supplements as well. Have anything worked for you? Thanks

Tiredofthis77 in reply to ks1974

Hello, I wish I could help, but nothing has worked for me so far... I think my problem is I'm a really poor converter of T4 to T3 so I'm looking at going down the T3 route.

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