Hi everyone. I've had hypothyroidism for 30 years and have blindly accepted the doctors' advice up to now. I've been taking Levothyroxine 100mg for years with no visible improvement and have been "signed off" by the consultant at Manchester Royal Infirmary. "Just keep taking the tablets" seems to be the order of the day but I'm not satisfied. I recently had an aortic valve replacement and my weight has ballooned despite a strict but healthy diet. I would like to know if anyone out there is taking Warfarin as well as Levothyroxine and if that mixture might be the cause of my severe weight gain (2 stone in 2 months). Any help would be gratefully received.